NCT07420608Completed
Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors
Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors: A Multicenter Randomized Controlled Trial With Longitudinal Follow Up
Source: ClinicalTrials.gov · Last updated 19 Feb 2026
Brief summary (registry, in English)
Stroke is a leading cause of long-term disability, with balance and gait deficits affecting \>80% of survivors and increasing fall risk. Emerging evidence links ankle proprioceptive impairment-particularly inversion/eversion acuity-to these deficits, often bilateral and central in origin. Cross-sectional studies show strong associations, but causality, temporal progression, and intervention efficacy (especially in severe/non-ambulatory cases) remain unproven. This trial tests a targeted proprioceptive protocol against standard care.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 140 (actual)
- First submitted
- 4 Feb 2026
- Start date
- 1 Jan 2023
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Iqra National University
- Diseases
- Stroke
- NCT number
- NCT07420608
What you commit to
- Study type: Interventional
- Participants enrolled: 140
- From 1 Jan 2023 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent conflicting trials
Other illness
- Acute medical issues (e.g., uncontrolled hypertension)
- Severe cognitive impairment (MMSE \<24)
Other
- Exercise contraindications
Who the study is looking for
- Clinical diagnosis of chronic ischemic/hemorrhagic stroke (≥12 months post-stroke)
- Moderate-to-severe lower extremity impairment (Fugl-Meyer LE ≤28 or NIHSS motor leg ≥2)
- Documented ankle proprioceptive deficit (AMEDA AUC \<0.7)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IQRA National University Coordinator of this site? Confirm its status | Swat | Pakistan | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.