NCT07420738Recruiting
Effects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG Surgery
The Effects of Different Extracorporeal Circulation Techniques on Cerebral Perfusion Markers and Postoperative Awakening in Coronary Artery Bypass Graft Surgery
Source: ClinicalTrials.gov · Last updated 5 Aug 2026
Brief summary (registry, in English)
This prospective study aims to compare the effects of minimal invasive extracorporeal circulation (MiECC) and conventional reservoir-based extracorporeal circulation techniques on cerebral perfusion in patients undergoing elective coronary artery bypass graft (CABG) surgery. Although the adverse effects of cardiopulmonary bypass on cerebral perfusion and oxygenation are well recognized, the relationship between these effects and changes in intracranial pressure has not been fully elucidated. In this context, ultrasonographic measurement of optic nerve sheath diameter (ONSD), a non-invasive surrogate marker of intracranial pressure, will be used in combination with near-infrared spectroscopy (NIRS) to enable a comprehensive assessment of cerebral perfusion and oxygenation. Between February 2026 and February 2027, a total of 70 ASA II-III patients scheduled for elective CABG surgery will be prospectively enrolled and allocated according to the extracorporeal circulation technique used. Perioperative ONSD measurements will be performed by a single anesthesiologist blinded to the perfusion technique. The primary endpoint is the comparison of perioperative changes in ONSD between the two techniques. Secondary endpoints include the correlation between ONSD and NIRS values, incidence of cerebrovascular events, extubation time, duration of intensive care unit and hospital stay, perioperative hemodynamic parameters, and postoperative complications. This study is expected to provide clinically relevant data on the cerebral effects of different extracorporeal circulation strategies and contribute to perioperative neuromonitoring practices in cardiac surgery.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 70 (estimated)
- First submitted
- 4 Feb 2026
- Start date
- 1 May 2026
- Primary completion date
- 1 May 2027
- Lead sponsor
- Kartal Kosuyolu High Speciality Training and Research Hospital
- Diseases
- High blood pressure
- NCT number
- NCT07420738
What you commit to
- Study type: Observational
- Planned participants: 70
- From 1 May 2026 to the primary completion date, 1 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergency surgery
- History of head trauma within the previous 24 hours
Other illness
- History of neurological disease affecting consciousness or decision-making capacity
- History of psychiatric disease affecting decision-making capacity
- Presence of carotid artery stenosis or significant carotid artery disease
- Reoperation (redo cardiac surgery)
- Congestive heart failure
- Chronic kidney failure
Lab values
- Coagulation disorders (INR \> 1.25, aPTT \> 35 s, or platelet count \< 100,000/μL)
Age
- Age \< 18 years
Other
- ASA physical status other than II-III
- Pregnancy
- Sepsis
- Hypoxia
- Ocular trauma
- Optic nerve pathology
Who the study is looking for
- Age ≥ 18 years
- Scheduled for elective coronary artery bypass graft (CABG) surgery
- American Society of Anesthesiologists (ASA) physical status II-III
- Planned use of extracorporeal circulation during surgery
- Ability to provide written informed consent
Age in the registry: 18 years to 75 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kosuyolu High Specialization Training and Research Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.