NCT07422103Not yet recruiting
PAN-CLO-BU (PANcreas-CLOstridium-BUtyricum)
Supplementation With Clostridium Butyricum CBM588 in Patients Undergoing Pancreaticoduodenectomy for Periampullary Neoplasms: A Prospective Randomized Double-Blind Study
Source: ClinicalTrials.gov · Last updated 19 Feb 2026
Brief summary (registry, in English)
This is a prospective, randomized, double-blind, single-center clinical trial designed to evaluate the effects of Clostridium butyricum CBM588 supplementation on postoperative diarrhea, gastrointestinal symptoms, and quality of life in patients undergoing pancreaticoduodenectomy for periampullary neoplasms. Oncological outcomes, including disease-free survival and overall survival, will be monitored as secondary endpoints during follow-up.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 158 (estimated)
- First submitted
- 3 Feb 2026
- Start date
- 15 Mar 2026
- Primary completion date
- 30 Nov 2028
- Lead sponsor
- Casa di Cura Dott. Pederzoli
- Diseases
- Pancreatic cancer
- NCT number
- NCT07422103
What you commit to
- Study type: Interventional
- Planned participants: 158
- From 15 Mar 2026 to the primary completion date, 30 Nov 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous or current use of Clostridium butyricum CBM588
- Neoadjuvant chemotherapy or radiotherapy
Age
- Age \< 18 years
Other
- Lactose intolerance
Who the study is looking for
- Age ≥ 18 years
- Written informed consent
- Patients undergoing pancreaticoduodenectomy
- Candidates for upfront surgery without previous neoadjuvant chemotherapy or radiotherapy
- Patients with benign or malignant periampullary neoplasms
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ospedale Pederzoli Coordinator of this site? Confirm its status | Peschiera del Garda | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.