NCT07422818Not yet recruiting
Non-invasive Evaluation of Patients With Angina and Non-obstructive Coronary Artery Disease
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
This is a single-center, prospective interventional study evaluating noninvasive coronary function testing using transthoracic Doppler echocardiography of the left anterior descending coronary artery in patients with stable angina and nonobstructive coronary artery disease (ANOCA) who previously underwent invasive coronary function testing (adenosine and/or acetylcholine). A group of age- and sex-matched healthy volunteers will be enrolled to support interpretation of potentially abnormal noninvasive responses observed in patients.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 35 (estimated)
- First submitted
- 21 Jan 2026
- Start date
- Mar 2026
- Primary completion date
- Oct 2026
- Lead sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Diseases
- Coronary artery disease
- NCT number
- NCT07422818
What you commit to
- Study type: Interventional
- Planned participants: 35
- From Mar 2026 to the primary completion date, Oct 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous coronary revascularization with surgical intervention;
Other illness
- Presentation as an acute coronary syndrome (i.e. unstable chest pain) or a typical history of variant angina (frequent angina pain at rest with ST-segment elevation at the ECG, caused by recurrent coronary spasm);
- Psychological conditions that might hamper patient co-operation;
- Any condition that, in the judgment of the investigators, would make difficult for the patient to complete the study protocol;
Lab values
- Serious medical conditions, including renal failure (eGFR \<30 mL/min), liver diseases, malignancies, and acute or chronic inflammatory diseases;
Other
- Asthma or known intolerance or contraindications to dipyridamole;
- Pregnancy;
- Missed informed consent.
Who the study is looking for
- Age between 18 and 90 years;
- ICA performed within the previous 12 months from enrollment and characterized by: (a) absence of obstructive CAD (\<50% diameter reduction or FFR by \>0.80); (b) invasive assessment of epicardial/microvascular spasm by acetylcholine test;
- Signed informed consent.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.