NCT07422974Recruiting
Perioperative Outcomes After Neoadjuvant Therapy in Colorectal Cancer
The Impact of Neoadjuvant Therapy on Perioperative Complications and Treatment Outcomes in Patients Undergoing Colorectal Cancer Resection
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
This prospective study investigates the effects of neoadjuvant therapy on endothelial function, microvascular tissue density, and tissue fibrosis in patients with colorectal cancer and their association with perioperative complications. The primary objective is to assess differences in microvascular tissue density between patients who received neoadjuvant therapy and those who did not, biomarkers, and demographic factors between patients who received neoadjuvant therapy and those who underwent surgery as initial treatment, and to compare clinical outcomes. The study will include 34 patients treated with neoadjuvant therapy and 34 patients for whom surgery is the first-line treatment. Patients will be followed until discharge from the hospital, and complications after discharge will be monitored through medical records one month after surgery.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 68 (estimated)
- First submitted
- 27 Jan 2026
- Start date
- 9 Jan 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Osijek University Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT07422974
What you commit to
- Study type: Observational
- Planned participants: 68
- From 9 Jan 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergency surgical cases
- Patients on chronic corticosteroid therapy
Age
- Age \<18 years
Other
- Patients who are not conscious, not oriented, or unable to provide informed consent
- Patients unable to understand the study protocol
Who the study is looking for
- Adults aged ≥18 years with histologically confirmed colorectal cancer
- Planned surgical treatment for colorectal cancer (either laparoscopic LPSC or open laparotomy)
- Ability to understand the study protocol and provide written informed consent.
- Both sexes
- ASA classification II or III
- Patients who received neoadjuvant therapy is investigational group and patients who did not receive neoadjuvant therapy is control group
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| KBC Osijek Coordinator of this site? Confirm its status | Osijek | Croatia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.