NCT07424027Recruiting
Central Vein Sign in Multiple Sclerosis Extension Study
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
Multiple sclerosis (MS) is a common disease of the central nervous system that affects almost 1 million people in the United States. However, diagnosing MS can be difficult and often leads to misdiagnosis. More sensitive and specific biomarkers are needed to help with the diagnosis, prognosis, and evaluation of treatment response for MS. The central vein sign (CVS) and the paramagnetic rim lesion (PRL) are two biomarkers that have shown promise in improving diagnostic accuracy for MS. The goal of this study is to provide pilot information on the long-term performance of the CVS and PRL to help diagnose and follow people with MS. The study will follow 40 participants over 48 months to determine if the CVS and PRL help make a diagnosis of MS and how they can be used to follow people with MS. The study will also examine how PRL and CVS change over 48 months. The results of this pilot study will inform the development of a grant application to extend 5-year follow-up for all 420 participants of the CAVS-MS study. The study will use high-resolution T2\*-weighted MRI to detect the CVS and PRLs. An MRI of the brain with contrast will be used to examine CVS, PRL and longitudinal analysis of lesions that slowly grow over time (slowly expanding lesions \[SELs\]). The results of this study have the potential to improve the accuracy of diagnosing and treating MS.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 11 Feb 2026
- Start date
- 7 Oct 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- The Cleveland Clinic
- Diseases
- Multiple sclerosis
- NCT number
- NCT07424027
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 7 Oct 2025 to the primary completion date, 31 Dec 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindication to MRI studies; metal or metal implants incompatible with MRI
Other
- Inability to tolerate MRI due to claustrophobia or known excessive movement (e.g. tremor).
Who the study is looking for
- Participants must be enrolled in and meet all inclusion criteria of the CAVS-MS study.
- Must have participated in the CAVS-MS study and have completed month 24 visits.
- Able to provide written informed consent to participate in the study.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Foundation Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
| Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Not yet recruiting |
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.