NCT07424963Recruiting
Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)
Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement. The primary question is whether EUS-PPG provides measurements really equivalent to HVPG in terms of gradient accuracy. Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 16 Feb 2026
- Start date
- May 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- Military University Hospital, Prague
- Diseases
- High blood pressure
- NCT number
- NCT07424963
What you commit to
- Study type: Interventional
- Planned participants: 40
- From May 2025 to the primary completion date, Dec 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Anticoagulation or antiplatelet therapy, which cannot be discontinued
- State after liver transplantation
Other illness
- Severe co-morbidities (e.g., advanced chronic heart failure, chronic renal insufficiency stage 4 and above, long-term poorly compensated diabetes mellitus with severe complications)
- Documented iodine contrast dye allergy
- Presence of portal vein thrombosis or cavernomatous transformation of portal vein or hepatic vein obstruction
Lab values
- INR \> 1.5 and/or platelet count \< 50,000/µl
Other
- Pregnancy
- Estimated patient non-compliance and/or not signing of the informed consent
- Ascites Grade 3
- Biliary obstruction
- Hepatocellular carcinoma in the left lobe of the liver
- Surgically altered upper gastrointestinal tract anatomy
- State after transjugular intrahepatic portosystemic shunt
Who the study is looking for
- Age 18-75 years at the time of enrollment; signed informed consent
- Clinical indication for HVPG measurement and/or transjugular liver biopsy for chronic advanced liver disease
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Military University Hospital Prague Coordinator of this site? Confirm its status | Prague | Czechia | Recruiting |
| IKEM Coordinator of this site? Confirm its status | Prague | Czechia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.