NCT07425093Completed
Investigation of the Relationship Between Gray and White Matter Volumes, Walking Exercise, and Body Fat Percentage in Adults With a Body Mass Index Above 25
Source: ClinicalTrials.gov · Last updated 20 Feb 2026
Brief summary (registry, in English)
This study examines the relationship between walking exercise, body fat percentage changes, and brain gray and white matter volumes in overweight and obese adults with headache complaints. Participants with a Body Mass Index (BMI) of 25 or above will be divided into two groups: one receiving a diet program combined with a 12-week walking exercise regimen, and a control group receiving diet alone. Both groups will undergo brain MRI scans and body composition measurements at baseline and after 12 weeks. The study aims to determine whether exercise-induced reductions in body fat percentage have a measurable impact on brain structure, specifically gray and white matter volumes. Blood tests will monitor metabolic markers throughout the intervention. This research may contribute to understanding how different types of exercise affect brain health and inform the development of more effective treatments for obesity-related neurological changes.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 22 (actual)
- First submitted
- 15 Feb 2026
- Start date
- 1 Jan 2024
- Primary completion date
- 1 Mar 2024
- Lead sponsor
- Amasya University
- Diseases
- Obesity
- NCT number
- NCT07425093
What you commit to
- Study type: Interventional
- Participants enrolled: 22
- From 1 Jan 2024 to the primary completion date, 1 Mar 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of antidepressant medications
Other illness
- Diagnosed chronic diseases including hypertension or diabetes
- Unable to use smartphone applications for heart rate monitoring and step counting, or does not own a smartphone
- History of cerebrovascular disease (stroke, transient ischemic attack)
- Diagnosis of epilepsy
- Diagnosis of Multiple Sclerosis or Alzheimer's disease
- Conditions affecting brain ventricular volume (e.g., hydrocephalus)
Lab values
- Did not complete required baseline blood tests (fasting glucose, lipid profile, liver enzymes, thyroid function, vitamin B12, hemogram, HbA1c) between January 1, 2024 and March 1, 2024
Other
- Did not present to the neurosurgery department with headache complaints between January 1, 2024 and March 1, 2024
- Did not undergo brain MRI between January 1, 2024 and March 1, 2024
- BMI \<25 kg/m²
- Unable or unwilling to attend 6 biweekly nutrition counseling sessions over 12 weeks
- Unable or unwilling to attend 6 biweekly body composition measurement appointments over 12 weeks
- Physical disabilities that would prevent walking exercise
- Currently engaged in regular exercise programs
- Pregnancy
- Currently breastfeeding
Who the study is looking for
- Adults aged 19-65 years
- Body Mass Index (BMI) ≥25 kg/m²
- Presented to the neurosurgery department with headache complaints between January 1, 2024 and March 1, 2024
- Underwent brain magnetic resonance imaging (MRI) between January 1, 2024 and March 1, 2024
- Completed baseline blood tests between January 1, 2024 and March 1, 2024, including:
- Fasting blood glucose
- Lipid profile (total cholesterol, LDL, HDL, triglycerides)
- Liver enzymes (ALT, AST, GGT)
- Thyroid function tests (T3, T4, TSH)
- Vitamin B12
- Complete blood count (hemogram)
- Hemoglobin A1c (HbA1c)
- Scheduled for routine 6-month follow-up blood work based on initial test results
- Willing to undergo follow-up brain MRI at 12 weeks (costs covered by research team)
- Willing and able to attend 6 biweekly nutrition counseling sessions over 12 weeks with the study dietitian
- Willing and able to attend 6 biweekly body composition measurement appointments over 12 weeks
- No diagnosed chronic conditions including hypertension or diabetes
- Owns a smartphone and is proficient in using smartphone applications for heart rate monitoring and step counting
Age in the registry: 19 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Amasya Sabuncuoglu Serefeddin Training and Research Hospital Coordinator of this site? Confirm its status | Amasya | Turkey (Türkiye) | Unknown status |
| Kolmed Hospital Coordinator of this site? Confirm its status | Amasya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.