NCT07425535RecruitingEarly phase 1
Optic Nerve Head Strain in Non-glaucoma Subjects
Source: ClinicalTrials.gov · Last updated 13 Jul 2026
Brief summary (registry, in English)
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 16 Feb 2026
- Start date
- 24 Jun 2026
- Primary completion date
- 1 Mar 2028
- Lead sponsor
- Johns Hopkins University
- Diseases
- Glaucoma
- NCT number
- NCT07425535
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 30
- From 24 Jun 2026 to the primary completion date, 1 Mar 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret
Other illness
- with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution.
- inability to understand English or with a language or hearing impairment
Other
- in whom sitting in an upright position is impossible due to physical disability
- in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable.
- who cannot perform home tonometry accurately at certification
- who do not have reliable clinical Optical Coherence Tomography (OCT) testing.
- with any form of glaucoma
- with high myopia defined as refractive error \> -8
Who the study is looking for
- Adults who have no history of OAG
- Have an ocular examination by a glaucoma specialist with no indications of OAG
- Have normal optical coherence tomography findings in the retinal nerve fiber layer.
- Over age 30 will be included from
- Both sexes
- All ethnic groups.
- Optic neuropathy.
- Both suspects and those with glaucoma damage will be included.
- When both eyes meet inclusion and exclusion criteria, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.
Age in the registry: 30 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins Hospital Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.