NCT07426354Enrolling by invitation
Multimodal Sensory Feedback and Mirror Therapy for Stroke Rehabilitation
Neural Mechanisms and Efficacy of Multimodal Sensory Feedback Augmentation on Mirror Therapy for Stroke Rehabilitation
Source: ClinicalTrials.gov · Last updated 23 Feb 2026
Brief summary (registry, in English)
The goal of this clinical trial is to investigate the clinical and neurophysiological effects of a novel multimodal sensory feedback mirror therapy in stroke survivors with upper extremity hemiparesis , aged between 20 and 85 years. The main questions it aims to answer are: 1. Does Multimodal Augmented Mirror Therapy (MAF-MT) lead to significantly greater improvements in functional recovery compared to unimodal digital mirror visual feedback mirror therapy (MVF-MT) or traditional mirror therapy (TMT) ? 2. What are the underlying neurophysiological changes in brain activation (mu rhythm desynchronization) and intermuscular coordination patterns associated with this hybridized feedback approach? Researchers will compare the MAF-MT group (receiving digital mirror visual feedback with multimodal sensory feedback) to the MVF-MT group (digital mirror feedback only) and the TMT group (traditional mirror therapy using the standard mirror box) to see if the integration of multimodal feedback leads to superior functional and brain acitivity outcomes. Participants will undergo eligibility screening including assessments of motor impairment and cognitive status. They will participate in 20 sessions of intervention, consisting of approximately 75 minutes of assigned therapies. They will receive specific sensory intervention depending on group assignment and complete evaluation (described in Outcome Measures) before the intervention, immediately after, and at a one-month follow-up
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 84 (estimated)
- First submitted
- 3 Feb 2026
- Start date
- 1 Aug 2025
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Asia University
- Diseases
- Stroke
- NCT number
- NCT07426354
What you commit to
- Study type: Interventional
- Planned participants: 84
- From 1 Aug 2025 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Uncontrolled major medical conditions, such as uncontrolled hypertension or heart failure, or concomitant neurological conditions, for example, dementia, Parkinson's disease, brain tumors, or other brain conditions
Other
- Severe neglect, as measured by the line bisection test
- Severe pain, swelling, spasticity or contractures in affected arms that prevent movement practice and assessments.
Who the study is looking for
- At least 3 months post-onset of a unilateral stroke
- Age between 20 and 85 years
- An initial Fugl-Meyer Assessment of Upper Extremity (FMA-UE) score between 18 and 56
- Ability to follow study instructions, as determined by a Montreal Cognitive Assessment (MoCA) score ≥ 18
- No concurrent participation in other neurorehabilitation studies or drug clinical trials
Age in the registry: 20 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Taipei Tzu Chi Hospital Coordinator of this site? Confirm its status | New Taipei City | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.