NCT07427069Not yet recruiting
Chronic Kidney Disease Associated Diet
The Role of Pro-Inflammatory Diet in Periodontal Tissue Destruction in Chronic Kidney Disease
Source: ClinicalTrials.gov · Last updated 24 Feb 2026
Brief summary (registry, in English)
The goal of this observational study is to investigate the relationship between chronic kidney disease (CKD) and periodontitis, and to evaluate the potential mediating role of dietary inflammatory potential, measured by the Dietary Inflammatory Index (DII), in this association. The main question it aims to answer is: Does a pro-inflammatory diet, as reflected by a higher DII score, exacerbate periodontal inflammation in individuals with chronic kidney disease? Participants will include adults diagnosed with CKD at various stages. Periodontal status will be assessed through clinical parameters such as probing depth, clinical attachment loss, and bleeding on probing. Dietary intake will be evaluated using a validated food frequency questionnaire, and DII scores will be calculated accordingly. The study will aim to observe and analyze whether dietary inflammation contributes to increased periodontal disease severity in CKD patients, potentially offering insight into modifiable risk factors relevant to both systemic and oral health.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 15 Feb 2026
- Start date
- 20 Apr 2026
- Primary completion date
- 19 Oct 2026
- Lead sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Diseases
- Chronic kidney disease
- NCT number
- NCT07427069
What you commit to
- Study type: Observational
- Planned participants: 100
- From 20 Apr 2026 to the primary completion date, 19 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Those taking medications that could affect periodontal tissues,
- Alcohol/drug use,
Other illness
- Patients with an active infectious disease,
- History of endocarditis,
- Psychological disorders,
- Eating disorders,
- Dementia,
Other
- Recent antibiotic use (within 4 months),
- Pregnancy and breastfeeding,
- Patients who did not sign the informed consent form
Who the study is looking for
- Being between 18 and 65 years of age
- Being diagnosed with Chronic Kidney Disease (having an eGFR below 60 ml/min/1.73 m² for at least 3 months or a urine albumin-to-creatinine ratio above 30 mg/g (proteinuria))
- Having at least 20 teeth
- Not having received periodontal therapy in the last 6 months
- Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
- Not having any autoimmune disease, osteoporosis, or cancer
- Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates
- Not being pregnant
- Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
- Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
- Not taking antioxidant supplements in the last 6 months
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University Coordinator of this site? Confirm its status | Rize | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.