NCT07429396Not yet recruiting
Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction
Source: ClinicalTrials.gov · Last updated 24 Feb 2026
Brief summary (registry, in English)
The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different "phenotypes" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET). The main questions this study aims to answer are: * Can clinical data be used to identify meaningful HFpEF phenotypes? * Do these phenotypes match well-known HFpEF scores, such as the H2FPEF and Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide (HFA-PEFF) scores? * Do people in different phenotypes show different results on a CPET? Participants will: * Have their past clinical records reviewed if they were diagnosed with HFpEF at the Local Health Unit of the Leiria Region (ULS RL); * A smaller group will attend one visit to complete a CPET, which measures how the heart, lungs and muscles respond during exercise. This study includes adults aged 18 years or older who have HFpEF. The study does not involve any new treatments or experimental drugs.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 12 Jan 2026
- Start date
- 1 Dec 2026
- Primary completion date
- 1 Aug 2027
- Lead sponsor
- Instituto Politécnico de Leiria
- Diseases
- Heart failure
- NCT number
- NCT07429396
What you commit to
- Study type: Observational
- Planned participants: 200
- From 1 Dec 2026 to the primary completion date, 1 Aug 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Retropective observational phase (Phase I):
- Incomplete or inadequate medical records preventing full data extraction.
- Cross-sectional observational phase (Phase II - CPET):
- Medical contraindication or physical inability to perform cardiopulmonary exercise testing (CPET);
- Inability to provide informed consent.
Who the study is looking for
- Retropective observational phase (Phase I):
- Age ≥18 years;
- Established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%);
- Patients receiving care (outpatient or inpatient) at the Local Health Unit of the Leiria Region (ULS RL) since September 2018.
- Cross-sectional observational phase (Phase II - CPET):
- Age ≥18 years;
- Established diagnosis of HFpEF;
- Selection as a volunteer representative of phenotypes identified in the retrospective clustering analysis;
- Provision of written informed consent prior to any study-specific procedures.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ciTechCare - Center for Innovative Care and Health Technology Coordinator of this site? Confirm its status | Leiria | Portugal | Unknown status |
| Local Health Unit of the Leiria Region Coordinator of this site? Confirm its status | Leiria | Portugal | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.