NCT07429526Completed
Does Aerobic Exercise Affect Memory and Fatigue After Acquired Brain Injury?
Does Aerobic Exercise Affect Memory, Attention, Working Memory, and Fatigue After Acquired Brain Injury? A Single-Blinded, Randomized Controlled Pilot Study
Source: ClinicalTrials.gov · Last updated 24 Feb 2026
Brief summary (registry, in English)
Acquired brain injury can affect cognition and cause fatigue. Aerobic exercise has been linked to improved cognition in the general population. This is thought to occur through boosting neuroplasticity, that is to say the brain's ability to change and adapt. Investigators explored the effects of aerobic exercise after acquired brain injury and investigated if any changes on the brain could be detected. This was done through an 8-week period of 30 min of aerobic exercise, 3-4 times a week for a group of 6 participants compared with 6 participants that did their usual training. Magnetic resonance imaging was used to detect any changes on the brain.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 12 (actual)
- First submitted
- 19 Nov 2025
- Start date
- 1 Nov 2013
- Primary completion date
- 1 Sept 2022
- Lead sponsor
- Danderyd Hospital
- Diseases
- Stroke
- NCT number
- NCT07429526
What you commit to
- Study type: Interventional
- Participants enrolled: 12
- From 1 Nov 2013 to the primary completion date, 1 Sept 2022
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- \- Severe heart disease
- Cognitive defects, not due to the actual stroke or TBI
Other
- Moderate depression/anxiety, defined as \>10 respectively on HADS
- Severe aphasia
- Not fulfilling criterias for MRI (such as pregnancy, having metal parts implanted in the body, afraid of cramped spaces)
Who the study is looking for
- \- First stroke/TBI with CT/MRI verified injury, (moderate to severe brain injury)
- Age 18-65 years
- at least 3 months after injury
- Fluent in Swedish Selection criteria
- Cognition:
- one standard deviation (SD) below age adjusted normal in at least one of the following tests: verbal memory, visual memory, working memory or attention
- be able to follow instructions during neuropsychological (NP) testing.
- be able to reach 60-80% of estimated maximal heart rate (HRmax= 220-age) during aerobic testing and training
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Danderyds Sjukhus, Rehabiliteringsmedicinska Universitets Kliniken Stockholm Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.