NCT07430254Not yet recruiting
Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia
Finger Plethysmographic Cardiac Output Monitoring to Predict Fluid Responsiveness in Healthy Pregnancy and Women Diagnosed With Preeclampsia and Severe Features
Source: ClinicalTrials.gov · Last updated 24 Feb 2026
Brief summary (registry, in English)
The goal of this observational study is to determine whether noninvasive finger plethysmographic cardiac output monitoring can help predict fluid responsiveness in pregnant women, including those with preeclampsia with severe features. The main questions it aims to answer are : * Can changes in cardiac output measured by finger plethysmography predict fluid responsiveness? * How does this method perform compared with standard echocardiographic assessment? Participants will provide consent and undergo noninvasive hemodynamic monitoring and a brief reversible physiological challenge.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 88 (estimated)
- First submitted
- 18 Feb 2026
- Start date
- Jul 2026
- Primary completion date
- Jul 2028
- Lead sponsor
- Stanford University
- NCT number
- NCT07430254
What you commit to
- Study type: Observational
- Planned participants: 88
- From Jul 2026 to the primary completion date, Jul 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Non-reassuring fetal heart tracing
- History of chronic arterial hypertension
- Chronic kidney disease
- Congenital or known acquired heart disease
- Chronic obstructive pulmonary disease
- Diabetes
- History of stroke
Other
- Patients who can not provide written consent to participate in the study
- BMI greater than 40 kg/m²
- Multiple pregnancy (twins, triplets, etc.)
- ≤ 22 weeks gestation
- Not tolerating passive leg raising (unable to be placed in the required study position)
- No TTE-windows
- Withdrawing consent
- Emergency cesarean delivery
Who the study is looking for
- Women diagnosed with preeclampsia with severe features following ACOG recommendations (systolic/diastolic BP \>160/110 mmHg, proteinuria, or other severe features like headaches, visual disturbances, kidney/liver impairment, thrombocytopenia).
- Healthy pregnant women at term (for comparison group, e.g., scheduled for elective Cesarean delivery).
Age in the registry: 18 years to - · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lucile Packard Children's Hospital Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.