NCT07430852Enrolling by invitation
Inherited and Environmental Risks Acting on Body Weight
Genetic and Environmental Contributions to Obesity Pathogenesis
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 18 Feb 2026
- Start date
- Oct 2026
- Primary completion date
- Nov 2029
- Lead sponsor
- University of Washington
- Diseases
- Obesity
- NCT number
- NCT07430852
What you commit to
- Study type: Interventional
- Planned participants: 110
- From Oct 2026 to the primary completion date, Nov 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics)
Other illness
- History of bariatric surgery or active participation in weight-loss program
- Major medical or neurological disorder (e.g., diabetes, multiple sclerosis)
- Individuals with severe food allergies and dietary restrictions (e.g., vegan/vegetarian, gluten-free, others) (study 2)
- Lifetime eating disorder
Lab values
- Known gallbladder disease, anemia, impaired thyroid, kidney or liver function or hypertriglyceridemia (\>350 mg/dl) (study 2)
Other
- High levels of vigorous physical activity (\>300 min./week)
- Pregnancy, menopause, or breastfeeding
- Co-twin unwilling or unable to participate
- MRI contraindication (e.g., implanted metal, claustrophobia)
- Current smoking or heavy alcohol use (≥ 2 drinks per day for females and ≥ 3 drinks per day for males)
- BMI \> 45 kg/m2 (study 1)
- BMI \> 35 kg/m2 (study 2)
- Weight \> 350 pounds or determined to be safe by MRI tech (MRI limit)
- Inability to participate in a controlled diet program (study 2) or undergo other study procedures
- Non-English speaking-or-reading individuals
Who the study is looking for
- Age 20-45 years
- Differs in habitual diet from co-twin (study 1).
- Willing to undergo 7-day overfeeding and hypocaloric feeding periods (study 2)
- Member of the Washington State Twin Registry
Age in the registry: 20 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Washington Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.