NCT07431580Recruiting
Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.
Effect of Acute Hypoxia on RIght VEntRicular Function. A Single-Center, Double-Blind, Randomized Controlled Cross-Over Trial.
Source: ClinicalTrials.gov · Last updated 29 May 2026
Brief summary (registry, in English)
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with asthma responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with asthma. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The "altitude" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 18 (estimated)
- First submitted
- 9 Feb 2026
- Start date
- 26 May 2026
- Primary completion date
- Jan 2030
- Lead sponsor
- Mona Lichtblau
- Diseases
- Asthma
- NCT number
- NCT07431580
What you commit to
- Study type: Interventional
- Planned participants: 18
- From 26 May 2026 to the primary completion date, Jan 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)
Other illness
- Any other diagnosed cardiopulmonary condition including past HAPE
- Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders
Age
- \<18, \>80 years old
Other
- Participants permanently living \>800m and altitude exposure \> 2500 m and \>24h within the last three weeks
- Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy
- Lactating women
- Participation in other study with active treatment
Who the study is looking for
- Signed informed consent
- Diagnosed and well controlled asthma bronchiale
- 18-80 years (age group young: 18-39.99 years / age group older: 40-80 years)
- All sex and genders
- Living \<800m and without altitude exposure \> 2500 m and \> 24h within the last three weeks
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Consultant Clinic of Pulmonology, University Hospital of Zurich Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.