NCT07431593Recruiting
Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications
Clinical Significance and Prognostic Value of Systemic Immune Inflammation Index and Systemic Inflammation Response Index in Obesity and Associated Metabolic Complications
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
This observational study aims to evaluate the diagnostic and prognostic value of the systemic immune-inflammatory index (SII) and the systemic inflammation response index (SIRI) in individuals with overweight or obesity. The study will assess their association with obesity status, metabolic complications, lifestyle patterns, dietary indices, and established inflammatory biomarkers. Participants will undergo anthropometric assessment, laboratory testing, dietary evaluation, and follow-up for response to different obesity treatment modalities over 3 years. The study intends to determine whether SII and SIRI can serve as clinically useful predictors of metabolic risk and treatment outcomes of obesity.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 11 Feb 2026
- Start date
- Apr 2026
- Primary completion date
- 28 Apr 2027
- Lead sponsor
- University of Rijeka
- Diseases
- Obesity
- NCT number
- NCT07431593
What you commit to
- Study type: Observational
- Planned participants: 200
- From Apr 2026 to the primary completion date, 28 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of immunosuppressive therapy
- Recent major surgery (within the last 3 months)
Other illness
- Active infection
- Inflammatory disease
- Malignancy
- Acute illness affecting immune parameters
- Conditions interfering with study participation (as assessed by the investigator)
- Chronic inflammatory diseases requiring systemic therapy
- Any condition that could confound the relationship between SII/SIRI and obesity-driven inflammation, such as immune disorders
Lab values
- Known hematologic disorders affecting leukocyte or platelet counts
Other
- Pregnancy or breastfeeding
Who the study is looking for
- Age ≥ 18 years
- BMI 25.0-29.9 kg/m² (overweight) or BMI ≥ 30 kg/m² (obesity)
- Ability to attend scheduled clinical visits
- Willingness to provide informed consent
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| General Hospital Varazdin Coordinator of this site? Confirm its status | Varaždin | Croatia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.