NCT07432620Active, not recruiting
Artificial Intelligence Stress Echo (FINESSE) Project
Risk Prediction Model in Patients With Suspected Coronary Artery Disease Based on Contemporary Stress Echocardiography Data Using Artificial Intelligence
Source: ClinicalTrials.gov · Last updated 25 Feb 2026
Brief summary (registry, in English)
The goal of this observational study is to learn whether combining stress echocardiography (stress echo) results with routine clinical information can better predict important heart outcomes in adults (18+) with chest pain who were assessed for suspected coronary artery disease. The main questions it aims to answer are: Can an artificial intelligence / machine learning model using stress echo findings plus clinical factors (such as blood pressure, diabetes, smoking, other health conditions, medications, and body measurements) predict major heart-related events (such as heart attack, stroke, death related to heart disease, or the need for coronary procedures) more accurately than stress echo results alone? Can the model help identify which patients are most likely to benefit from further invasive assessment and possible coronary revascularisation (for example, a stent or bypass surgery)? Which combination of stress echo measurements and clinical factors contributes most to risk prediction? Participants will: Not be asked to attend extra visits or have additional tests for this study. Have their existing stress echo reports and routinely collected hospital record data analysed (approximately 3,000 people who previously had dobutamine stress echo at Milton Keynes University Hospital). In some cases, if outcomes are not fully available from hospital records, the research team may check additional sources (such as GP records, or contacting the patient if appropriate) to confirm whether a major heart-related event occurred.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 2281 (actual)
- First submitted
- 9 Feb 2026
- Start date
- 7 Jun 2019
- Primary completion date
- 4 Nov 2023
- Lead sponsor
- Milton Keynes University Hospital NHS Foundation Trust
- Diseases
- Coronary artery disease, Stroke
- NCT number
- NCT07432620
What you commit to
- Study type: Observational
- Participants enrolled: 2281
- From 7 Jun 2019 to the primary completion date, 4 Nov 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Age under 18 years at the time of the index stress echocardiography.
Other
- No available/usable stress echocardiography report for extraction into the study database.
- Unable to link the record to follow-up outcome information using routine hospital systems (with attempted supplementary checks where needed).
- Patients who have registered a National Data Opt-out and are therefore not eligible for use of their confidential patient information for research/secondary purposes in this study.
Who the study is looking for
- Age 18 years or older at the time of the index stress echocardiography.
- Referred for pharmacological (dobutamine) stress echocardiography at Milton Keynes University Hospital for assessment of suspected coronary artery disease / chest pain.
- Stress echocardiography report available in the hospital dataset for data extraction and conversion into a structured database.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Milton Keynes University Hospital Coordinator of this site? Confirm its status | Milton Keynes | United Kingdom | Unknown status |
Related publications
- The FINESSE (Artificial Intelligence Stress Echo) study to develop and validate machine learning-based model to improve risk prediction in patients undergoing stress echocardiography for the assessment of inducible myocardial ischaemia (FINESSE Protocol).Eur Heart J Imaging Methods Pract · 2026 · PMID 42695072
This page is information, not medical advice. Discuss any trial with your doctor.