NCT07433088Not yet recruiting
Validation of Virtual Reality Tests for the Assessment of Patients With Age-related Macular Degeneration as Clinical Endpoints
Validation of Virtual Reality Tests for the Assessment of Patients With Age-related Macular Degeneration
Source: ClinicalTrials.gov · Last updated 25 Feb 2026
Brief summary (registry, in English)
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized countries and affects tens of millions of people worldwide, with a rapidly increasing prevalence. It causes irreversible central vision loss and significant difficulties in daily activities, impairing patients' quality of life and independence. Conventional clinical assessments, which focus on visual acuity and retinal imaging, do not fully reflect the functional impact of the disease. Virtual reality (VR) makes it possible to create immersive, controlled environments to accurately measure functional vision and simulate real-life situations. The study proposes to develop a standardized and reproducible functional test in virtual reality that can complement conventional examinations and support clinical and industrial research.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 11 Feb 2026
- Start date
- Apr 2026
- Primary completion date
- Apr 2027
- Lead sponsor
- Streetlab
- Diseases
- Macular degeneration
- NCT number
- NCT07433088
What you commit to
- Study type: Interventional
- Planned participants: 60
- From Apr 2026 to the primary completion date, Apr 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any concomitant intraocular condition in the eye being studied (e.g., glaucoma or cataract)
- Participation in any other therapeutic study evaluating a drug.
Other illness
- Subjects undergoing drug treatments that may cause motor, visual, vestibular, or cognitive disorders (PSA, neuroleptics, etc.) or that could interfere with the study examinations
- Known systemic disease that, in the investigator's opinion, would prevent active participation in the study
- Subjects with cognitive impairment, illiterate subjects, and subjects who do not speak the national language.
Other
- Pregnant women, women in labor, or breastfeeding women
- Any retinal pathology that could cause retinal atrophy other than AMD (eliminate dystrophy, chronic CRSC, pachyatrophy, resorption of vitelliform material with atrophy, high myopia, etc.)
- Persons subject to enhanced protection or legal safeguards (guardianship, trusteeship).
Who the study is looking for
- Age ≥ 50 years
- Sufficient knowledge of the French language
- Ability to give personal, express, free, and informed consent
- Ability to comply with the requirements of the protocol
- Person covered by Social Security
- Clarity of the ocular environment, adequate pupil dilation to allow the collection of good quality images, as determined by the investigator
- Additional inclusion criteria for group 1, healthy subjects:
- No detectable visual pathologies
- Best monocular visual acuity ≥ 8/10
- Additional inclusion criteria for group 2, subjects with LMA, early AMD, or intermediate AMD without atrophy:
- Diagnosis of AMD, early AMD, or intermediate AMD
- Absence of geographic atrophy
- Presence of drusen (diameter \> 63 µm) with or without pigmentary changes
- Additional inclusion criteria for group 3, subjects with dry AMD with perifoveal atrophy:
- Diagnosis of atrophic AMD
- Presence of drusen (diameter \> 125 µm)
- Location of geographic atrophy as determined by the investigator: extrafoveal, juxtafoveal
- Preservation of central vision confirmed by the investigator based on a comprehensive and integrated interpretation of SD-OCT, FAF, retinography, and best corrected visual acuity examinations.
- Additional inclusion criteria for group 4, Subject with dry AMD with foveal atrophy:
- Diagnosis of atrophic AMD
- Presence of drusen (diameter \> 125 µm)
- Investigator's localization of geographic atrophy: retrofoveal
- Central vision impairment confirmed by the investigator based on a comprehensive and integrated interpretation of SD-OCT, FAF, retinography, and best corrected visual acuity examinations.
Age in the registry: 50 years to - · Sex: All · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.