NCT07436377Active, not recruiting
THE RELATİONSHİP BETWEEN BLOOD GAS PARAMETERS OBTAİNED FROM THE CORONARY SİNUS DURİNG THE PROCEDURE AND CRT RESPONSE İN PATİENTS WİTH HEART FAİLURE WHO UNDERWENT CRT IMPLANTATİON
Source: ClinicalTrials.gov · Last updated 27 Feb 2026
Brief summary (registry, in English)
Heart failure (HF) is one of the clinical syndromes with the highest morbidity and mortality rates among cardiovascular diseases. Despite pharmacological treatments, symptoms persist in a significant proportion of patients, and mortality cannot be prevented. Therefore, device-based therapies, particularly cardiac resynchronisation therapy (CRT), have gained an important place in the treatment algorithm.CRT aims to correct mechanical dyssynchrony by enabling simultaneous contraction of the left and right ventricles. It also aims to reduce sudden cardiac death rates with its defibrillator feature. Current guidelines emphasise that CRT provides significant benefits in terms of symptomatic improvement and long-term survival when appropriate patient selection is made. However, not all patients who meet the criteria have benefited equally from CRT. It is difficult to predict in advance which heart failure patients will benefit from CRT.The aim of the study is to analyse blood gas parameters obtained from the coronary sinus during the procedure in cases of symptomatic heart failure with low ejection fraction despite optimal medical treatment and in patients with indications for CRT according to current guidelines. This analysis aims to contribute to the prior identification of patients who may benefit.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 65 (actual)
- First submitted
- 20 Feb 2026
- Start date
- 1 Sept 2022
- Primary completion date
- 1 Sept 2024
- Lead sponsor
- Trakya University
- Diseases
- Heart failure
- NCT number
- NCT07436377
What you commit to
- Study type: Observational
- Participants enrolled: 65
- From 1 Sept 2022 to the primary completion date, 1 Sept 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Not receiving the maximum tolerable dose of medication for KY.
- Patients scheduled for CRT prior to nodal ablation.
Other illness
- History of acute myocardial infarction within the last 3 months.
- History of cardiac surgery within the last 3 months.
- Elective cardiac surgery planned.
- Chronic lung diseases (COPD, emphysema, bronchitis, etc.). -
Other
- Patients with EF 35 or higher.
- QRS duration on ECG less than 130 milliseconds.
- Absence of left bundle branch block morphology on ECG.
- Estimated life expectancy of less than 1 year.
- Patients with intracardiac shunts.
- Those who refuse to participate in the study.
Who the study is looking for
- Patients diagnosed with heart failure, with an EF \<35, and in heart failure stages 2-3-4 despite optimal medical therapy.
- Those who agree to participate in the study.
- Patients aged 18 years and older.
- Patients with a QRS duration of 135 ms or more on ECG.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Trakya University Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Edirne | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.