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NCT07440225RecruitingPhase 2/3

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)

Source: ClinicalTrials.gov · Last updated 2 Oct 2026

Brief summary (registry, in English)

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Status (registry)
Recruiting
Phase (registry)
Phase 2/3
Study type
Interventional
Enrollment
960 (estimated)
First submitted
23 Feb 2026
Start date
27 Mar 2026
Primary completion date
30 Jun 2028
Lead sponsor
EyeBiotech Ltd.
NCT number
NCT07440225

What you commit to

  • Study type: Interventional · Phase 2/3
  • Planned participants: 960
  • From 27 Mar 2026 to the primary completion date, 30 Jun 2028
  • 132 sites in 12 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Criteria the registry did not label

  • The main inclusion criteria include but are not limited to the following:
  • Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
  • The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment
    • The main exclusion criteria include but are not limited to the following
  • Has uncontrolled blood pressure at screening
  • History of any prior macular laser photocoagulation in the study eye
  • History of uveitis in either eye
  • History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
  • Has uncontrolled glaucoma in the study eye
  • Active retinal disease other than the condition under investigation in the study eye
  • Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye

Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (132)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Instituto Oftalmologico de Buenos Aires SA (Site 306)
Coordinator of this site? Confirm its status
Buenos AiresArgentinaRecruiting
Centro de Ojos Loria SRL (Site 312)
Coordinator of this site? Confirm its status
Buenos AiresArgentinaRecruiting
Centro Oftalmologico Dr Charles y Asociados (Site 300)
Coordinator of this site? Confirm its status
Buenos AiresArgentinaRecruiting
Centro Oftalmológico Dr. Zas
Coordinator of this site? Confirm its status
Buenos AiresArgentinaRecruiting
Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302)
Coordinator of this site? Confirm its status
Buenos AiresArgentinaRecruiting
RSresearch (Site 308)
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Buenos AiresArgentinaRecruiting
Clinica Privada de Ojos
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Buenos AiresArgentinaRecruiting
Centro de Ojos Quilmes
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Buenos AiresArgentinaRecruiting
Instituto Donato
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Cdad. Autónoma de Buenos AiresArgentinaRecruiting
Hospital Britanico- Microcentro
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Cdad. Autónoma de Buenos AiresArgentinaRecruiting
Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305)
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CórdobaArgentinaRecruiting
Centro Privado de Ojos Romagosa SA (Site 307)
Coordinator of this site? Confirm its status
CórdobaArgentinaRecruiting
Centrovision Clinica Oftalmologica
Coordinator of this site? Confirm its status
MendozaArgentinaRecruiting
Oftar Centro De Oftalmología en Mendoza
Coordinator of this site? Confirm its status
MendozaArgentinaRecruiting
Microcirugia Ocular Rosario (Site 310)
Coordinator of this site? Confirm its status
RosarioArgentinaRecruiting
Oftalmología Global (Centro Médico Oftalmología Global) (Site 304)
Coordinator of this site? Confirm its status
RosarioArgentinaRecruiting
Grupo Laser Vision (Rosario Eximer Laser Vision SA)
Coordinator of this site? Confirm its status
RosarioArgentinaRecruiting
Centro de la Visión (Site 309)
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SaltaArgentinaRecruiting
Instituto Zeman Bardeci (Site 311)
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SaltaArgentinaRecruiting
Centro de la Vision
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SaltaArgentinaRecruiting
Eye Clinic Albury Wodonga (Site 425)
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AlburyAustraliaRecruiting
Retina and Eye Consultants
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HurstvilleAustraliaRecruiting
Retina and Macula Specialists
Coordinator of this site? Confirm its status
Hurstville, SydneyAustraliaRecruiting
Launceston Eye Doctors
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LauncestonAustraliaRecruiting
Nexus Eyecare
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NorwestAustraliaRecruiting
Marsden Eye Specialists (Site 420)
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ParramattaAustraliaRecruiting
Marsden Eye Specialists (Site 423)
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StrathfieldAustraliaRecruiting
Sydney Retina Clinic and Day Surgery (Site 424)
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SydneyAustraliaRecruiting
Sydney Eye Hospital (Site 426)
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SydneyAustraliaRecruiting
University Hospital Basel, Eye Clinic
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BaselSwitzerlandRecruiting
Swiss Eye Institute and Berner Augenklinik
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BernSwitzerlandRecruiting
Vista Augenklinik Binningen
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BinnigenSwitzerlandRecruiting
Fondation Asile des aveugles (Hôpital Ophtalmique Jules-Gonin)
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LausanneSwitzerlandRecruiting
Stadtspital Zurich Triemli Forschungszentrum Augenklinik
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ZurichSwitzerlandRecruiting
Universitätsklinikum Hamburg Eppendorf Klinik und Poliklinik für Augenheilkunde
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HamburgGermanyRecruiting
Augenzentrum am St. Franziskus-Hospital Münster
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MünsterGermanyRecruiting
Silmalaser OÜ
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TallinnEstoniaRecruiting
Silmaarst Krista Turman OÜ
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TallinnEstoniaRecruiting
East Tallinn Central Hospital
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TallinnEstoniaRecruiting
Tartu University Hospital
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TartuEstoniaRecruiting
Hospital Universitari Vall d'Hebron - despacho de coordinación de oftalmología. Planta 8, Edifici General
Coordinator of this site? Confirm its status
BarcelonaSpainRecruiting
Clinica de Oftalmologia Barraquer
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BarcelonaSpainRecruiting
Hospital Universitario Puerta de Hierro - Majadahonda
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MadridSpainRecruiting
University Hospitals of Leicester NHS Trust (Site 209)
Coordinator of this site? Confirm its status
LeicesterUnited KingdomRecruiting
South West Retina
Coordinator of this site? Confirm its status
LiverpoolUnited KingdomRecruiting
London North West University Healthcare NHS Trust (LNWH) (Site 201)
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LondonUnited KingdomRecruiting
Barzilai Medical Center
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AshkelonIsraelRecruiting
Carmel Medical Center (Site 704)
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HaifaIsraelRecruiting
Rambam Health Corporation (Site 706)
Coordinator of this site? Confirm its status
HaifaIsraelRecruiting
Hadassah Medical Center Opthalmology Department (Site 701)
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JerusalemIsraelRecruiting
Rabin Medical Center (Site 700)
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Petah TikvaIsraelRecruiting
Sheba Medical Center (Site 707)
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Ramat GanIsraelRecruiting
Kaplan Medical Center Ophthalmology Department (Site 705)
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RehovotIsraelRecruiting
Shamir Medical Center (Site 703)
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TsrifinIsraelRecruiting
Riga East University hospital, clinical centre Bikernieki
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RigaLatviaRecruiting
P. Stradins Clinical University Hospital
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RigaLatviaRecruiting
Northern Kurzeme Regional Hospital
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VentspilsLatviaRecruiting
OFTALMIKA Sp. z o.o
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BydgoszczPolandRecruiting
Oculomedica Eye Hospital
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BydgoszczPolandRecruiting
Profesorskie Centrum Medyczne Sp. z o.o.
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GdanskPolandRecruiting
Gabinet Okulistyczny Edward Wylęgała
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KatowicePolandRecruiting
Dietla Medical Center 19 Sp zoo
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KrakowPolandRecruiting
Klinika okulistyczna w Olsztynie - Centrum Diagnostyki i Mikrochirurgii Oka Lens
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OlsztynPolandRecruiting
Caminomed Sp. zo.o
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Tarnowskie GóryPolandRecruiting
Centro Oftalmologico Metropolitano
Coordinator of this site? Confirm its status
San JuanPuerto RicoRecruiting
Retina Research Institute of Texas (Site 010)
Coordinator of this site? Confirm its status
AbileneUnited StatesRecruiting
Palmetto Retina Center
Coordinator of this site? Confirm its status
AikenUnited StatesRecruiting
Vision Research Center Eye Associates of New Mexico
Coordinator of this site? Confirm its status
AlbuquerqueUnited StatesRecruiting
Florida Eye Clinic (Site 130)
Coordinator of this site? Confirm its status
Altamonte SpringsUnited StatesRecruiting
Southwest Retina Specialists
Coordinator of this site? Confirm its status
AmarilloUnited StatesRecruiting
Texas Retina Associates
Coordinator of this site? Confirm its status
ArlingtonUnited StatesRecruiting
Austin Research Center for Retina
Coordinator of this site? Confirm its status
AustinUnited StatesRecruiting
Austin Retina Associates (Site 012)
Coordinator of this site? Confirm its status
AustinUnited StatesRecruiting
Retina & Vitreous of Texas
Coordinator of this site? Confirm its status
BellaireUnited StatesRecruiting
Mid Atlantic Retina (Site 050)
Coordinator of this site? Confirm its status
BethlehemUnited StatesRecruiting
Charleston Neuroscience Institute - Bluffton (Site 124)
Coordinator of this site? Confirm its status
BlufftonUnited StatesRecruiting
Pacific Northwest Retina (Site 112)
Coordinator of this site? Confirm its status
BurlingtonUnited StatesRecruiting
Associated Vitreoretinal and Uveitis Consultants
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CarmelUnited StatesRecruiting
Midwest Eye Institute
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CarmelUnited StatesRecruiting
Charleston Neuroscience Institute (Site 104)
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CharlestonUnited StatesRecruiting
Retina Consultants, PLLC
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CharlestonUnited StatesRecruiting
Mid Atlantic Retina
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Cherry HillUnited StatesRecruiting
Cincinnati Eye Institute (Site 133)
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CincinnatiUnited StatesRecruiting
Texas Retina Associates
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DallasUnited StatesRecruiting
Retina Vitreous Center
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EdmondUnited StatesRecruiting
Retina Center of Arkansas
Coordinator of this site? Confirm its status
FayettevilleUnited StatesRecruiting
Retina Group of Florida (Site 070)
Coordinator of this site? Confirm its status
Fort LauderdaleUnited StatesRecruiting
Vitreo Retinal Associates
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GainesvilleUnited StatesRecruiting
Charles Retina Institute
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GermantownUnited StatesRecruiting
Global Research Management, Inc
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GlendaleUnited StatesRecruiting
Foundation for Vision Research (Site 073)
Coordinator of this site? Confirm its status
Grand RapidsUnited StatesRecruiting
Piedmont Retina Specialists - Greensboro
Coordinator of this site? Confirm its status
GreensboroUnited StatesRecruiting
North Carolina Retina Associates
Coordinator of this site? Confirm its status
GreenvilleUnited StatesRecruiting
Cumberland Valley Retina Consultants (Site 007)
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HagerstownUnited StatesRecruiting
Retina Specialists of Mississippi
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HattiesburgUnited StatesRecruiting
ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)
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HauppaugeUnited StatesRecruiting
Florida Retina Institute
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JacksonvilleUnited StatesRecruiting
Florida Retina Consultants
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LakelandUnited StatesRecruiting
Retina Vitreous Surgeons of CNY, PC (Site 033)
Coordinator of this site? Confirm its status
LiverpoolUnited StatesRecruiting
Piedmont Eye Center (Site 054)
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LynchburgUnited StatesRecruiting
Mississippi Retina Associates (Site 084)
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MadisonUnited StatesRecruiting
South Florida Retina Institute
Coordinator of this site? Confirm its status
MiamiUnited StatesRecruiting
Retinal Consultants Medical Group (Site 024)
Coordinator of this site? Confirm its status
ModestoUnited StatesRecruiting
Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina
Coordinator of this site? Confirm its status
Mt. PleasantUnited StatesRecruiting
Illinois Retina Associates
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Oak ParkUnited StatesRecruiting
Retina Care Specialists
Coordinator of this site? Confirm its status
Palm Beach GardensUnited StatesRecruiting
Azul Vision / California Eye Specialists Medical Group, Inc.
Coordinator of this site? Confirm its status
PasadenaUnited StatesRecruiting
Texas Retina (Site 037)
Coordinator of this site? Confirm its status
PlanoUnited StatesRecruiting
Fort Lauderdale Eye Institute (Site 042)
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PlantationUnited StatesRecruiting
EyeHealth Northwest
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PortlandUnited StatesRecruiting
Retina Northwest, PC
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PortlandUnited StatesRecruiting
Retina Consultants of Southern California (Site 043)
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RedlandsUnited StatesRecruiting
Retinal Consultants Medical Group (Site 022)
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SacramentoUnited StatesRecruiting
Retinal Consultants Medical Group (Site 020)
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SacramentoUnited StatesRecruiting
Retina Consultants of Minnesota
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Saint Louis ParkUnited StatesRecruiting
Retina Associates of Utah
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Salt Lake CityUnited StatesRecruiting
Research Network Arizona / Retina Macula Institute of Arizona
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ScottsdaleUnited StatesRecruiting
Retina Center of Texas
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SouthlakeUnited StatesRecruiting
Spokane Eye Clinical Research (Site 075)
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SpokaneUnited StatesRecruiting
Retina Partners of Northwest Arkansas, PLLC
Coordinator of this site? Confirm its status
SpringdaleUnited StatesRecruiting
Springfield Clinic
Coordinator of this site? Confirm its status
SpringfieldUnited StatesRecruiting
Retina Vitreous Associates of Florida (Site 049)
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St. PetersburgUnited StatesRecruiting
Southern Vitreoretinal Associates
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TallahasseeUnited StatesRecruiting
Retina Associates of Florida, LLC
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TampaUnited StatesRecruiting
Retina Vitreous Associates of Florida
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TampaUnited StatesRecruiting
Retina Consultants of Texas (Site 014)
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The WoodlandsUnited StatesRecruiting
Tulsa Retina Consultants
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TulsaUnited StatesRecruiting
Tyler Retina Research Institute
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TylerUnited StatesRecruiting
Eye Clinic of Wisconsin
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WausauUnited StatesRecruiting
Strategic Clinical Research Group
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WeatherfordUnited StatesRecruiting
Wildwood Clinical Research / Florida Retina Institute
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WildwoodUnited StatesRecruiting
Piedmont Retina Specialists - Winston-Salem
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Winston-SalemUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.