NCT07440225RecruitingPhase 2/3
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 960 (estimated)
- First submitted
- 23 Feb 2026
- Start date
- 27 Mar 2026
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- EyeBiotech Ltd.
- Diseases
- Macular degeneration
- NCT number
- NCT07440225
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 960
- From 27 Mar 2026 to the primary completion date, 30 Jun 2028
- 132 sites in 12 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- The main inclusion criteria include but are not limited to the following:
- Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye)
- The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment
- The main exclusion criteria include but are not limited to the following
- Has uncontrolled blood pressure at screening
- History of any prior macular laser photocoagulation in the study eye
- History of uveitis in either eye
- History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study
- Has uncontrolled glaucoma in the study eye
- Active retinal disease other than the condition under investigation in the study eye
- Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (132)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Instituto Oftalmologico de Buenos Aires SA (Site 306) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Centro de Ojos Loria SRL (Site 312) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Centro Oftalmologico Dr Charles y Asociados (Site 300) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Centro Oftalmológico Dr. Zas Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| RSresearch (Site 308) Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Clinica Privada de Ojos Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Centro de Ojos Quilmes Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Instituto Donato Coordinator of this site? Confirm its status | Cdad. Autónoma de Buenos Aires | Argentina | Recruiting |
| Hospital Britanico- Microcentro Coordinator of this site? Confirm its status | Cdad. Autónoma de Buenos Aires | Argentina | Recruiting |
| Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305) Coordinator of this site? Confirm its status | Córdoba | Argentina | Recruiting |
| Centro Privado de Ojos Romagosa SA (Site 307) Coordinator of this site? Confirm its status | Córdoba | Argentina | Recruiting |
| Centrovision Clinica Oftalmologica Coordinator of this site? Confirm its status | Mendoza | Argentina | Recruiting |
| Oftar Centro De Oftalmología en Mendoza Coordinator of this site? Confirm its status | Mendoza | Argentina | Recruiting |
| Microcirugia Ocular Rosario (Site 310) Coordinator of this site? Confirm its status | Rosario | Argentina | Recruiting |
| Oftalmología Global (Centro Médico Oftalmología Global) (Site 304) Coordinator of this site? Confirm its status | Rosario | Argentina | Recruiting |
| Grupo Laser Vision (Rosario Eximer Laser Vision SA) Coordinator of this site? Confirm its status | Rosario | Argentina | Recruiting |
| Centro de la Visión (Site 309) Coordinator of this site? Confirm its status | Salta | Argentina | Recruiting |
| Instituto Zeman Bardeci (Site 311) Coordinator of this site? Confirm its status | Salta | Argentina | Recruiting |
| Centro de la Vision Coordinator of this site? Confirm its status | Salta | Argentina | Recruiting |
| Eye Clinic Albury Wodonga (Site 425) Coordinator of this site? Confirm its status | Albury | Australia | Recruiting |
| Retina and Eye Consultants Coordinator of this site? Confirm its status | Hurstville | Australia | Recruiting |
| Retina and Macula Specialists Coordinator of this site? Confirm its status | Hurstville, Sydney | Australia | Recruiting |
| Launceston Eye Doctors Coordinator of this site? Confirm its status | Launceston | Australia | Recruiting |
| Nexus Eyecare Coordinator of this site? Confirm its status | Norwest | Australia | Recruiting |
| Marsden Eye Specialists (Site 420) Coordinator of this site? Confirm its status | Parramatta | Australia | Recruiting |
| Marsden Eye Specialists (Site 423) Coordinator of this site? Confirm its status | Strathfield | Australia | Recruiting |
| Sydney Retina Clinic and Day Surgery (Site 424) Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
| Sydney Eye Hospital (Site 426) Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
| University Hospital Basel, Eye Clinic Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
| Swiss Eye Institute and Berner Augenklinik Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
| Vista Augenklinik Binningen Coordinator of this site? Confirm its status | Binnigen | Switzerland | Recruiting |
| Fondation Asile des aveugles (Hôpital Ophtalmique Jules-Gonin) Coordinator of this site? Confirm its status | Lausanne | Switzerland | Recruiting |
| Stadtspital Zurich Triemli Forschungszentrum Augenklinik Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
| Universitätsklinikum Hamburg Eppendorf Klinik und Poliklinik für Augenheilkunde Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
| Augenzentrum am St. Franziskus-Hospital Münster Coordinator of this site? Confirm its status | Münster | Germany | Recruiting |
| Silmalaser OÜ Coordinator of this site? Confirm its status | Tallinn | Estonia | Recruiting |
| Silmaarst Krista Turman OÜ Coordinator of this site? Confirm its status | Tallinn | Estonia | Recruiting |
| East Tallinn Central Hospital Coordinator of this site? Confirm its status | Tallinn | Estonia | Recruiting |
| Tartu University Hospital Coordinator of this site? Confirm its status | Tartu | Estonia | Recruiting |
| Hospital Universitari Vall d'Hebron - despacho de coordinación de oftalmología. Planta 8, Edifici General Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Clinica de Oftalmologia Barraquer Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Universitario Puerta de Hierro - Majadahonda Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| University Hospitals of Leicester NHS Trust (Site 209) Coordinator of this site? Confirm its status | Leicester | United Kingdom | Recruiting |
| South West Retina Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| London North West University Healthcare NHS Trust (LNWH) (Site 201) Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Barzilai Medical Center Coordinator of this site? Confirm its status | Ashkelon | Israel | Recruiting |
| Carmel Medical Center (Site 704) Coordinator of this site? Confirm its status | Haifa | Israel | Recruiting |
| Rambam Health Corporation (Site 706) Coordinator of this site? Confirm its status | Haifa | Israel | Recruiting |
| Hadassah Medical Center Opthalmology Department (Site 701) Coordinator of this site? Confirm its status | Jerusalem | Israel | Recruiting |
| Rabin Medical Center (Site 700) Coordinator of this site? Confirm its status | Petah Tikva | Israel | Recruiting |
| Sheba Medical Center (Site 707) Coordinator of this site? Confirm its status | Ramat Gan | Israel | Recruiting |
| Kaplan Medical Center Ophthalmology Department (Site 705) Coordinator of this site? Confirm its status | Rehovot | Israel | Recruiting |
| Shamir Medical Center (Site 703) Coordinator of this site? Confirm its status | Tsrifin | Israel | Recruiting |
| Riga East University hospital, clinical centre Bikernieki Coordinator of this site? Confirm its status | Riga | Latvia | Recruiting |
| P. Stradins Clinical University Hospital Coordinator of this site? Confirm its status | Riga | Latvia | Recruiting |
| Northern Kurzeme Regional Hospital Coordinator of this site? Confirm its status | Ventspils | Latvia | Recruiting |
| OFTALMIKA Sp. z o.o Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Recruiting |
| Oculomedica Eye Hospital Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Recruiting |
| Profesorskie Centrum Medyczne Sp. z o.o. Coordinator of this site? Confirm its status | Gdansk | Poland | Recruiting |
| Gabinet Okulistyczny Edward Wylęgała Coordinator of this site? Confirm its status | Katowice | Poland | Recruiting |
| Dietla Medical Center 19 Sp zoo Coordinator of this site? Confirm its status | Krakow | Poland | Recruiting |
| Klinika okulistyczna w Olsztynie - Centrum Diagnostyki i Mikrochirurgii Oka Lens Coordinator of this site? Confirm its status | Olsztyn | Poland | Recruiting |
| Caminomed Sp. zo.o Coordinator of this site? Confirm its status | Tarnowskie Góry | Poland | Recruiting |
| Centro Oftalmologico Metropolitano Coordinator of this site? Confirm its status | San Juan | Puerto Rico | Recruiting |
| Retina Research Institute of Texas (Site 010) Coordinator of this site? Confirm its status | Abilene | United States | Recruiting |
| Palmetto Retina Center Coordinator of this site? Confirm its status | Aiken | United States | Recruiting |
| Vision Research Center Eye Associates of New Mexico Coordinator of this site? Confirm its status | Albuquerque | United States | Recruiting |
| Florida Eye Clinic (Site 130) Coordinator of this site? Confirm its status | Altamonte Springs | United States | Recruiting |
| Southwest Retina Specialists Coordinator of this site? Confirm its status | Amarillo | United States | Recruiting |
| Texas Retina Associates Coordinator of this site? Confirm its status | Arlington | United States | Recruiting |
| Austin Research Center for Retina Coordinator of this site? Confirm its status | Austin | United States | Recruiting |
| Austin Retina Associates (Site 012) Coordinator of this site? Confirm its status | Austin | United States | Recruiting |
| Retina & Vitreous of Texas Coordinator of this site? Confirm its status | Bellaire | United States | Recruiting |
| Mid Atlantic Retina (Site 050) Coordinator of this site? Confirm its status | Bethlehem | United States | Recruiting |
| Charleston Neuroscience Institute - Bluffton (Site 124) Coordinator of this site? Confirm its status | Bluffton | United States | Recruiting |
| Pacific Northwest Retina (Site 112) Coordinator of this site? Confirm its status | Burlington | United States | Recruiting |
| Associated Vitreoretinal and Uveitis Consultants Coordinator of this site? Confirm its status | Carmel | United States | Recruiting |
| Midwest Eye Institute Coordinator of this site? Confirm its status | Carmel | United States | Recruiting |
| Charleston Neuroscience Institute (Site 104) Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
| Retina Consultants, PLLC Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
| Mid Atlantic Retina Coordinator of this site? Confirm its status | Cherry Hill | United States | Recruiting |
| Cincinnati Eye Institute (Site 133) Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| Texas Retina Associates Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Retina Vitreous Center Coordinator of this site? Confirm its status | Edmond | United States | Recruiting |
| Retina Center of Arkansas Coordinator of this site? Confirm its status | Fayetteville | United States | Recruiting |
| Retina Group of Florida (Site 070) Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Recruiting |
| Vitreo Retinal Associates Coordinator of this site? Confirm its status | Gainesville | United States | Recruiting |
| Charles Retina Institute Coordinator of this site? Confirm its status | Germantown | United States | Recruiting |
| Global Research Management, Inc Coordinator of this site? Confirm its status | Glendale | United States | Recruiting |
| Foundation for Vision Research (Site 073) Coordinator of this site? Confirm its status | Grand Rapids | United States | Recruiting |
| Piedmont Retina Specialists - Greensboro Coordinator of this site? Confirm its status | Greensboro | United States | Recruiting |
| North Carolina Retina Associates Coordinator of this site? Confirm its status | Greenville | United States | Recruiting |
| Cumberland Valley Retina Consultants (Site 007) Coordinator of this site? Confirm its status | Hagerstown | United States | Recruiting |
| Retina Specialists of Mississippi Coordinator of this site? Confirm its status | Hattiesburg | United States | Recruiting |
| ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105) Coordinator of this site? Confirm its status | Hauppauge | United States | Recruiting |
| Florida Retina Institute Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Florida Retina Consultants Coordinator of this site? Confirm its status | Lakeland | United States | Recruiting |
| Retina Vitreous Surgeons of CNY, PC (Site 033) Coordinator of this site? Confirm its status | Liverpool | United States | Recruiting |
| Piedmont Eye Center (Site 054) Coordinator of this site? Confirm its status | Lynchburg | United States | Recruiting |
| Mississippi Retina Associates (Site 084) Coordinator of this site? Confirm its status | Madison | United States | Recruiting |
| South Florida Retina Institute Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Retinal Consultants Medical Group (Site 024) Coordinator of this site? Confirm its status | Modesto | United States | Recruiting |
| Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina Coordinator of this site? Confirm its status | Mt. Pleasant | United States | Recruiting |
| Illinois Retina Associates Coordinator of this site? Confirm its status | Oak Park | United States | Recruiting |
| Retina Care Specialists Coordinator of this site? Confirm its status | Palm Beach Gardens | United States | Recruiting |
| Azul Vision / California Eye Specialists Medical Group, Inc. Coordinator of this site? Confirm its status | Pasadena | United States | Recruiting |
| Texas Retina (Site 037) Coordinator of this site? Confirm its status | Plano | United States | Recruiting |
| Fort Lauderdale Eye Institute (Site 042) Coordinator of this site? Confirm its status | Plantation | United States | Recruiting |
| EyeHealth Northwest Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
| Retina Northwest, PC Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
| Retina Consultants of Southern California (Site 043) Coordinator of this site? Confirm its status | Redlands | United States | Recruiting |
| Retinal Consultants Medical Group (Site 022) Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
| Retinal Consultants Medical Group (Site 020) Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
| Retina Consultants of Minnesota Coordinator of this site? Confirm its status | Saint Louis Park | United States | Recruiting |
| Retina Associates of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
| Research Network Arizona / Retina Macula Institute of Arizona Coordinator of this site? Confirm its status | Scottsdale | United States | Recruiting |
| Retina Center of Texas Coordinator of this site? Confirm its status | Southlake | United States | Recruiting |
| Spokane Eye Clinical Research (Site 075) Coordinator of this site? Confirm its status | Spokane | United States | Recruiting |
| Retina Partners of Northwest Arkansas, PLLC Coordinator of this site? Confirm its status | Springdale | United States | Recruiting |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Recruiting |
| Retina Vitreous Associates of Florida (Site 049) Coordinator of this site? Confirm its status | St. Petersburg | United States | Recruiting |
| Southern Vitreoretinal Associates Coordinator of this site? Confirm its status | Tallahassee | United States | Recruiting |
| Retina Associates of Florida, LLC Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| Retina Vitreous Associates of Florida Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| Retina Consultants of Texas (Site 014) Coordinator of this site? Confirm its status | The Woodlands | United States | Recruiting |
| Tulsa Retina Consultants Coordinator of this site? Confirm its status | Tulsa | United States | Recruiting |
| Tyler Retina Research Institute Coordinator of this site? Confirm its status | Tyler | United States | Recruiting |
| Eye Clinic of Wisconsin Coordinator of this site? Confirm its status | Wausau | United States | Recruiting |
| Strategic Clinical Research Group Coordinator of this site? Confirm its status | Weatherford | United States | Recruiting |
| Wildwood Clinical Research / Florida Retina Institute Coordinator of this site? Confirm its status | Wildwood | United States | Recruiting |
| Piedmont Retina Specialists - Winston-Salem Coordinator of this site? Confirm its status | Winston-Salem | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.