NCT07441928Recruiting
Effects of Smoking on Network Connectivity in Patients With Schizophrenia Symptoms in Scz Patients
Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Acceptance and Commitment Therapy for Smoking Cessation and Reduction of Psychotic Symptoms in Patients With Schizophrenia
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
The prevalence of smoking among people with schizophrenia (SCZ) is substantially higher at 54% to 90% (McClave et al., 2010). About half of all deaths amongst people with scz are attributed to smoking-related diseases and cancer involving the lung, the cardiovascular system, and the liver (Kely et al., 2011; WHO, 2019). Acceptance and commitment therapy (ACT) is effective for treating psychotic symptoms and addictive behaviours. In a local randomised controlled trial comparing individual ACT to social support for smoking cessation in adult scz smokers, the self-reported quit rates in ACT group were higher than in the social support group (6 months: 12.3% vs. 7.7%, p=0.56 ; 12 months: 10.8% vs. 7.7%, p=0.76; Mak, Loke, and Leung, 2021). In this study, functional neuroimaging (fMRI) will be combined with symptoms assessment in order to ascertain whether group-based ACT is effective in modifying the brain's responses in general and specifically to tobacco craving cues and resting-state functional connectivity in three time points (pre-, post-intervention, and 6-month follow-up) among people with schizophrenia.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 23 Feb 2026
- Start date
- 1 Mar 2023
- Primary completion date
- 30 Apr 2026
- Lead sponsor
- The Hong Kong Polytechnic University
- Diseases
- Schizophrenia
- NCT number
- NCT07441928
What you commit to
- Study type: Interventional
- Planned participants: 90
- From 1 Mar 2023 to the primary completion date, 30 Apr 2026
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a lifetime history of substance abuse and/or are currently receiving treatment for substance abuse (e.g., opioids, cocaine, marijuana, or stimulants);
- Have received a diagnosis of alcohol or drug dependence in the year preceding recruitment;
Other illness
- Have any other current or past psychotic disorders;
- with a known history of violence/aggression and a forensic history
- Have a history or current diagnosis of attention-deficit hyperactivity disorder (ADHD);
- Have a history of epilepsy or a seizure disorder;
- Experience disorientation, have developmental disabilities, and/or an organic mental disorder;
Other
- with fleeting or actual suicidal/self-harm ideations, or acting-out behavior in the past;
- Categorized with special care or intensive care (e.g., arson, battery, physical assault, rape, murder, etc.)
- With alcohol consumption exceeding 25 standard drinks/week for men and 20 standard drinks/week for women over the last 6 months;
- Are pregnant, breast-feeding, or planning a pregnancy for the duration of the study;
- fMRI-related exclusion criteria promulgated by University Research Facility in Behavioural and Systems Neuroscience (UBSN), PolyU
Who the study is looking for
- Individuals who have been diagnosed with schizophrenia or schizoaffective disorder and after at least one-year followup;
- currently taking anti-psychotic medications for ≥ 3 months with good compliance;
- aged 18 years or above;
- able to communicate in Cantonese
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Out-patient Clinic (Psy), Pamela Youde Nethersole Eastern Hospital Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Recruiting |
| The Society of Rehabilitation and Crime Prevention Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Recruiting |
| Lok Hong Integrated Community Centre for Mental Wellness, Tung Wah Group of Hospitals Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Recruiting |
| The Mental Health Association of Hong Kong Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Recruiting |
| Mental Health and Development, Christian Family Service Centre Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.