NCT07442526Active, not recruiting
AGECTO Study: PCI vs. Optimal Medical Therapy for CTO in the Octogenarian Patients
AGECTO Study: A Comparative Study of Percutaneous Coronary Intervention vs. Medical Therapy for Chronic Total Occlusion in Octogenarian Patients
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
The study compares an interventional strategy (PCI) with optimal medical therapy (OMT) in ultra-octogenarians with chronic total occlusions (CTO). Results suggest that successful PCI leads to significant improvements in symptoms and quality of life compared to OMT alone. While initially carrying higher procedural risks, CTO-PCI is considered feasible and safe in experienced centers. There is also potential for long-term benefits in survival and a reduction in major adverse cardiovascular events (MACE). The choice between treatments depends on an individual risk-benefit assessment, considering the patient's overall condition.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 24 Feb 2026
- Start date
- 1 Jul 2025
- Primary completion date
- 1 Sept 2025
- Lead sponsor
- San Luigi Gonzaga Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT07442526
What you commit to
- Study type: Observational
- Planned participants: 200
- From 1 Jul 2025 to the primary completion date, 1 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe non-cardiac comorbidities with a life expectancy \< 1 year.
Other
- CTOs in the native vessel and patency grafts in CABG patients
- CTOs in the minor vessel (Non dominant RCA, small diagonal or obtuse marginal branch)
- Lack of any anatomical or clinical details of the patient
Who the study is looking for
- Age ≥ 80 years.
- CTO in at least one major coronary artery.
- Complete revascularization or non-critical stenosis in the non-CTO vessels.
- Life expectancy \> 1-year
Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rivoli Hospital Coordinator of this site? Confirm its status | Rivoli | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.