NCT07442747RecruitingPhase 2
Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS
Neural Mechanisms Underlying the Benefits of Aerobic Exercise in Advanced Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 26 Oct 2026
Brief summary (registry, in English)
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 24 Feb 2026
- Start date
- 8 Jul 2026
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- The Cleveland Clinic
- Diseases
- Parkinson disease
- NCT number
- NCT07442747
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 36
- From 8 Jul 2026 to the primary completion date, 31 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Neurocognitive impairment that compromises the ability to provide informed consent
- Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke)
- Current cardiac arrhythmia
Other
- A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in exercise
Who the study is looking for
- Clinical diagnosis of Parkinson's disease
- Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD
- Clinically optimized DBS parameters for one month prior to enrollment
- Ability to ambulate with or without an assistive device for 5 continuous minutes
- Willingness to withhold antiparkinsonian medication and DBS stimulation for outcomes assessments
- Medical clearance for moderate-high intensity exercise given by treating physician or physician extender
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.