NCT07442916Completed
Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication Overuse
Identification of Predictors of Treatment Response and Innovative Therapeutic Strategies Based on Non-Invasive Brain Stimulation in Patients With Chronic Migraine and Medication Overuse
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
This randomized, double-blind, sham-controlled clinical trial aims to evaluate the efficacy of non-invasive brain stimulation as an add-on treatment to standard detoxification therapy in patients with chronic migraine and medication overuse. The study also seeks to identify sensory and biochemical biomarkers predictive of treatment response.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 19 Feb 2026
- Start date
- 2 Jan 2024
- Primary completion date
- 30 Jan 2026
- Lead sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
- Diseases
- Migraine
- NCT number
- NCT07442916
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 2 Jan 2024 to the primary completion date, 30 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Changes in preventive migraine therapy within the last 3 months
- Ongoing treatment with monoclonal antibodies for migraine prevention
Other illness
- Major psychiatric disorders (e.g., major depressive disorder)
- Other significant neurological or systemic diseases
Other
- Pregnancy
- Contraindications to transcranial magnetic stimulation (for main study participants)
Who the study is looking for
- Diagnosis of chronic migraine and medication overuse according to ICHD-3 criteria
- Ability to provide written informed consent
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Translational Neurophysiology Coordinator of this site? Confirm its status | Pavia | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.