NCT07443150Completed
The Effect of BWSTT on Neuroendocrine Profile and Functional Recovery in Stroke Patients
Effects of Intensive Body Weight Support Treadmill Training (BWSTT) on Neurohormonal Profile and Functional Outcomes in Subacute Stroke Patients: A Randomized Controlled Trial.
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the impact of intensive Body Weight Support Treadmill Training (BWSTT) on the neuroendocrine system and functional recovery in patients during the subacute phase of ischemic stroke. The investigators aim to determine how structured locomotor training influences the concentration of selected neurohormones and how these changes correlate with improvements in gait and balance. Participants undergo a 3-week intensive rehabilitation program, with assessments performed before and after the intervention to identify biomarkers of recovery.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 19 Feb 2026
- Start date
- 3 Jul 2017
- Primary completion date
- 20 Apr 2019
- Lead sponsor
- Jagiellonian University
- Diseases
- Stroke
- NCT number
- NCT07443150
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 3 Jul 2017 to the primary completion date, 20 Apr 2019
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pharmacological Interference: Use of Selective Serotonin Reuptake Inhibitors (SSRIs) or other medications significantly affecting the neuroendocrine profile (e.g., hormone replacement therapy, corticosteroids).
Other illness
- Neurological Profile: Hemorrhagic stroke, recurrent stroke, bilateral stroke, or lesions localized in the cerebellum or brainstem.
- Functional Dependence: Requirement for constant, hands-on physical assistance from third parties to maintain upright gait (despite the use of orthopedic aids).
- Medical Contraindications: Cardiorespiratory instability (e.g., uncontrolled hypertension, cardiac arrhythmia), recent fractures, or advanced degenerative joint changes preventing safe verticalization.
- Communication \& Cognitive Barriers: Global or profound sensory aphasia, or severe cognitive impairment (MMSE \< 23) preventing effective cooperation.
- Co-morbidities: Any neurologic (e.g., Parkinson's disease, multiple sclerosis), orthopedic, rheumatological, or internal conditions (including active malignancy, severe systemic infections, or untreated metabolic disorders) that could interfere with the intervention's safety or the integrity of hormonal and functional assays.
Other
- Consent: Withdrawal of consent or lack of voluntary, written consent to participate in the study.
Who the study is looking for
- First-ever unilateral ischemic stroke (right or left hemisphere) confirmed by MRI.
- Subacute phase of stroke (between 2 and 6 weeks post-incident).
- Age between 45 and 85 years.
- Balance: A score of ≥ 21/56 points on the Berg Balance Scale (BBS), ensuring the ability to safely maintain a standing position.
- Mobility: Baseline gait speed ≥ 0.4 m/s (classified as Limited Community Ambulation).
- Permitted Aids: Use of orthopedic aids (quadripod, cane, walker) and foot stabilization (e.g., Thera-Band).
- Physical Capacity: Ability to complete the 6-Minute Walk Test (6MWT) without requiring rest breaks.
- Cognitive Status: MMSE score ≥ 23 (ensuring the ability to understand and follow instructions).
- Informed, written patient consent provided in accordance with the Declaration of Helsinki.
Age in the registry: 45 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Małopolski Szpital Rehabilitacyjny Coordinator of this site? Confirm its status | Krzeszowice | Poland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.