NCT07443293Active, not recruitingPhase 2

IMPACT 360 for Parkinson's Disease

IMPACT 360 Study for Parkinson's Disease

Source: ClinicalTrials.gov · Last updated 25 Jun 2026

Brief summary (registry, in English)

The IMPACT 360 study will evaluate the effects of a combined intervention of exercise, mindfulness, and nutrition on 8 key indicators of health and the mechanisms that drive these changes. 60 subjects aged 40 to 85 with a current diagnosis Parkinson's disease will be recruited. This study will follow a partial crossover design. All participants will receive the intervention. Participants randomized into the intervention group after their baseline screening will receive the 6-month intervention. Those randomized into the waitlist group will complete another assessment at the end of the 6-month care as usual phase before receiving the intervention.

Status (registry): Active, not recruiting
Phase (registry): Phase 2
Study type: Interventional
Enrollment: 60 (estimated)
First submitted: 24 Feb 2026
Start date: 28 Oct 2024
Primary completion date: 31 Dec 2026
Lead sponsor: University of British Columbia
Diseases: Parkinson disease
NCT number: NCT07443293

What you commit to

Study type: Interventional · Phase 2
Planned participants: 60
From 28 Oct 2024 to the primary completion date, 31 Dec 2026
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

Subjects with a history or major episodes of drug or alcohol abuse
Ear or eye implant
Implanted drug infusion pump
Surgery or tattoos (including tattooed eyeliner) in the last six weeks
Brain surgery

Other illness

Any chronic medical condition which would affect ability to participate in exercise
Significant cognitive impairment, depression, or eating disorder
Significant or unstable cardiovascular or respiratory disease
Chronic/acute bacterial/viral infection
GI cancer
Inflammatory bowel disease
- Exclusion for MRI scanning:
Artificial heart valve
Have a cardiac pacemaker, wires or defibrillator

Lab values

Any contraindication for exercise based on the Physical Activity Readiness for Everyone Questionnaire (PAR-Q+) and medical clearance form

Other

Score \<21/30 on the Montreal Cognitive Assessment (MoCA)
Any contraindication to MRI scanning; such as implanted metal clips or wires (see list below)
Participants who were told by a medical doctor that they need to be medically supervised for exercise
Participants currently doing 180 minutes or more of moderate-vigorous intensity exercise per week AND either of the following:
- Completion of a Mindfulness-Based Stress Reduction course OR; Score \>8/15 in the MIND Diet Questionnaire
Severe/multiple head trauma(s)
Subjects who are pregnant or breastfeeding
Individuals weighing \> 400 lbs (limit of MRI machine)
Brain aneurysm clip
Electrical stimulator for nerves or bones
Coil, catheter, or filter in any blood vessel
Orthopedic hardware (artificial joint, plate, screws)
Other metallic prostheses
Shrapnel, bullets, or other metal fragments
Have had an injury where a piece of metal lodged in the eye or orbit
Have a ferromagnetic aneurysm clip

Who the study is looking for

Age 40-85 years
A diagnosis of either PD, based on the Movement Disorder Society (MDS) criteria, OR, RBD, through a polysomnography
Hoehn \& Yahr score of 1 to 2
Able to fill out questionnaires
Able to follow instructions and directions as required by the intervention.
Have access to the necessary technologies (i.e., a working smartphone for Fitbit, a laptop or tablet for Zoom) as required by the intervention.

Age in the registry: 40 years to 85 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
University of British Colombia Coordinator of this site? Confirm its status	Vancouver	Canada	Unknown status

This page is information, not medical advice. Discuss any trial with your doctor.