NCT07443670Recruiting
Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure
Voice Analysis Using Artificial Intelligence to Detect Changes in Pulmonary Arterial Pressure in Patients With Heart Failure and an Implanted Pressure Sensor
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
VAPP-HF is a prospective, multi-center, observational study assessing whether daily voice recordings analyzed by a machine learning algorithm can detect changes in pulmonary arterial (PA) pressure in heart failure patients with implanted PA pressure sensors (e.g., CardioMEMS, Cordella). Patients across three sites in Germany and the United States provide daily voice recordings via a mobile app for 12 weeks while continuing standard PA pressure monitoring and heart failure care. Voice data is analyzed retrospectively after study completion; no clinical decisions are based on voice analysis during the study. The primary endpoint is the sensitivity and specificity of the AI-based voice analysis in detecting PA pressure changes at defined thresholds.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 24 Feb 2026
- Start date
- 12 Dec 2024
- Primary completion date
- May 2026
- Lead sponsor
- Noah Labs
- Diseases
- Heart failure
- NCT number
- NCT07443670
What you commit to
- Study type: Observational
- Planned participants: 60
- From 12 Dec 2024 to the primary completion date, May 2026
- 3 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pathological voice changes due to surgery or injury
- COPD requiring home oxygen therapy
Other illness
- Condition that in the opinion of the investigator would compromise patient safety or data quality
- Planned invasive cardiac procedures during the study period
- Chronic kidney disease requiring dialysis
Other
- Pregnant, breastfeeding, or unwilling to practice birth control during participation
- Cognitive dysfunction limiting ability to perform daily voice recording
- Inability to read English or German
- Physical inability to use the recording device
Who the study is looking for
- Age 18 years or older
- Successful implantation of a PA pressure sensor and monitored by a participating study center
- Willingness to record a short predefined text daily for 3 months using a smartphone or tablet
- Ability to comfortably read aloud the study passage in English or German
- Written informed consent obtained
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| BG Klinikum Unfallkrankenhaus Berlin, Dept. of Cardiology Coordinator of this site? Confirm its status | Berlin | Germany | Completed |
| University Hospital Frankfurt, Dept. of Cardiology and Angiology Coordinator of this site? Confirm its status | Frankfurt | Germany | Completed |
| University of California, San Francisco (UCSF) Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.