NCT07443696RecruitingPhase 2
PET Myocardial Fatty-acid Metabolic Imaging With XTR003 Injection and 18F-FDG to Assess Myocardial Viability in Ischemic Cardiomyopathy
A Randomized, Open-Label, Parallel-Controlled Phase IIb Clinical Trial of PET Myocardial Fatty-acid Metabolic Imaging With XTR003 Injection Integrated With 18F-FDG for the Assessment of Myocardial Viability in Patients With Ischemic Cardiomyopathy
Source: ClinicalTrials.gov · Last updated 2 Mar 2026
Brief summary (registry, in English)
This is a prospective, multicenter, randomized, open-label, parallel-controlled Phase IIb study to investigate the diagnostic-prognostic utility of XTR003 Injection integrated with 18F-FDG as an exploratory clinical trial. A total of 40-60 patients will be enrolled and randomized into two study groups as: fasting XTR003/18F-FDG group and glucose-loaded group at a 1:1 ratio. Each group will receive resting myocardial perfusion imaging (MPI) combined with metabolic PET imaging to evaluate myocardial metabolic activity and myocardial viability. Segmental perfusion abnormality, metabolic activity and myocardial viability will be analyzed according to the standard approaches in Nuclear Cardiology. Regional and global left ventricular function will be assessed with cardiac MRI and echocardiography prior to and post the completion of full revascularization within 6-month time point. A repeated resting MPI will also be performed to assess the improvement of perfusion abnormality. All study subjects will undergo 6 months follow-up for major adverse cardiac events (MACE).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 24 Dec 2025
- Start date
- 18 Dec 2025
- Primary completion date
- Aug 2026
- Lead sponsor
- Sinotau Pharmaceutical Group
- Diseases
- Heart failure
- NCT number
- NCT07443696
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 40
- From 18 Dec 2025 to the primary completion date, Aug 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Decompensated heart failure within 48 hours prior to enrollment.
- Contraindications to magnetic resonance imaging (MRI), such as claustrophobia or intracorporeal metallic implants.
- Significant occupational exposure to ionizing radiation (e.g., exceeding 50 mSv per year) or exposure to radioactive substances/ionizing radiation for therapeutic or research purposes within the past 10 years.
Other illness
- Recent ST-segment elevation myocardial infarction (STEMI) within less than 4 weeks.
- Severe renal insufficiency.
- Severe hepatic insufficiency.
- Subjects with fever or active infectious diseases who are assessed by the investigator as unsuitable for study participation.
- Subjects with mental disorders or poor compliance.
Other
- Left ventricular aneurysm.
- Judged by the investigator as unable to complete PET examination.
- Pregnant or lactating women.
- Other circumstances deemed by the investigator as unsuitable for trial participation.
Who the study is looking for
- Aged 18 to 85 years, regardless of gender.
- Diagnosed with ischemic cardiomyopathy (ICM).
- significant coronary artery disease (CAD).
- Left ventricular systolic dysfunction, with LVEF ranging from \>20% to ≤40%
- Assessed by a team of cardiac surgeons/operators as suitable for complete revascularization.
- Capable of effective communication with the investigators, able to understand and comply with the clinical study requirements, voluntarily participate in the study, and provide written informed consent after being fully informed.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Chaoyang Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Not yet recruiting |
| Beijing Anzhen Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
| TEDA International Cardiovascular Hospital Coordinator of this site? Confirm its status | Tianjin | China | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.