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NCT07445178Completed

Piecemeal Resection and Advanced Histology Independently Predict Local Recurrence After Colorectal Snare-based Endoscopic Resection: a Time-to-event Cohort Study

Source: ClinicalTrials.gov · Last updated 3 Mar 2026

Brief summary (registry, in English)

The objective of this retrospective cohort observational study is to identify variables related to the recurrence of colorectal lesions after snare polypectomy resection in colonoscopies. It also aims to evaluate the safety of the procedure. The main questions to be answered are: * What endoscopic characteristics are most related to recurrence? * What adverse events are related to the procedure? The researchers will perform a chart analysis looking for demographic, clinical, endoscopic, and histological variables in order to identify which factors are most closely linked to the recurrence of previously resected lesions.

Status (registry)
Completed
Study type
Observational
Enrollment
255 (actual)
First submitted
24 Feb 2026
Start date
4 Dec 2025
Primary completion date
15 Jan 2026
Lead sponsor
University of Sao Paulo
NCT number
NCT07445178

What you commit to

  • Study type: Observational
  • Participants enrolled: 255
  • From 4 Dec 2025 to the primary completion date, 15 Jan 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Patients undergoing techniques other than loop polypectomy, such as: Endoscopic submucosal dissection (ESD), advanced mucosal resection not based on conventional loop, primary surgical resection of the lesion;

Other illness

  • Invasive lesions beyond the mucosa (invasive cancer with deep submucosal invasion) that have been referred for immediate surgical treatment without endoscopic follow-up;

Other

  • Absence of follow-up colonoscopy, making it impossible to assess the primary outcome (local recurrence);
  • Incomplete clinical, endoscopic, or histopathological data that prevent adequate classification of study variables;
  • Loss to follow-up before the first surveillance colonoscopy.

Who the study is looking for

  • Age ≥ 18 years at the time of polypectomy;
  • Underwent snare polypectomy, with or without the use of thermal energy (cold snare or hot snare), performed during the study period (2023-2025);
  • Procedure performed at a participating tertiary center, ensuring technical and record standardization;
  • Availability of histopathological examination of the resected lesion, allowing for adequate histological characterization;
  • Performance of at least one documented surveillance colonoscopy, with evaluation of the previous resection site;
  • Adequate recording of clinical and endoscopic variables necessary for analysis (lesion size, location, resection technique, etc.);

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Hospital das Clínicas of Ribeirão Preto Medical School
Coordinator of this site? Confirm its status
Ribeirão PretoBrazilUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.