NCT07445451Completed
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
A Randomized Controlled Trial of the Analgesic, Hemodynamic, and Respiratory Effects of Intravenous Magnesium Sulfate and Dexmedetomidine Infusions During Transurethral Bladder Tumor Resection Under Spinal Anesthesia
Source: ClinicalTrials.gov · Last updated 3 Mar 2026
Brief summary (registry, in English)
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in patients undergoing elective transurethral resection of bladder tumor (TUR-M) under spinal anesthesia. Magnesium sulfate significantly reduced postoperative pain scores, delayed the time to first analgesic request, and decreased total analgesic consumption compared to dexmedetomidine and control groups, while both agents were hemodynamically and respiratorily safe.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 93 (actual)
- First submitted
- 16 Feb 2026
- Start date
- 15 Dec 2024
- Primary completion date
- 1 Sept 2025
- Lead sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
- Diseases
- Bladder cancer
- NCT number
- NCT07445451
What you commit to
- Study type: Interventional
- Participants enrolled: 93
- From 15 Dec 2024 to the primary completion date, 1 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Mental retardation, cognitive impairment, or communication difficulties that prevent understanding of study procedures or pain assessment.
Lab values
- History or current diagnosis of significant cardiac arrhythmia. Known allergy or contraindication to the study drugs (magnesium sulfate or dexmedetomidine).
Age
- Patients under 18 years or over 85 years of age. Contraindications to spinal anesthesia (e.g., infection at puncture site, coagulopathy).
Other
- Patients requiring conversion to general anesthesia due to inadequate spinal anesthesia intraoperatively.
- Patients who refuse to participate in the study.
- \-
Who the study is looking for
- Age between 18 and 85 years. Classified as ASA physical status I, II, or III according to the American Society of Anesthesiologists.
- Patients scheduled for elective transurethral resection of bladder tumor (TUR-M) under spinal anesthesia.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| SBÜ Kartal Dr. Lütfi Kırday City Hospital, İstanbul Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.