NCT07445620Not yet recruiting
Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia
Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia: DB-RCT
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
This randomized, double-blind, sham-controlled trial compares three brain stimulation approaches-accelerated intermittent theta burst stimulation (aITBS), high-frequency repetitive transcranial magnetic stimulation (HF-rTMS), and sham stimulation-for treating cognitive deficits in treatment-resistant schizophrenia. Ninety patients receiving clozapine will be randomized 1:1:1 to receive 20 sessions over 4 weeks targeting the dorsolateral prefrontal cortex. The primary outcome is change in cognitive function measured by B-CATS score at 2, 4, and 12 weeks. Secondary outcomes include social cognition, symptom severity, brain metabolism (FDG-PET), and inflammatory biomarkers.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 23 Feb 2026
- Start date
- 15 Sept 2026
- Primary completion date
- 14 Feb 2029
- Lead sponsor
- All India Institute of Medical Sciences, Bhubaneswar
- Diseases
- Schizophrenia
- NCT number
- NCT07445620
What you commit to
- Study type: Interventional
- Planned participants: 90
- From 15 Sept 2026 to the primary completion date, 14 Feb 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently receiving or recently received ECT/rTMS/tDCS
Other illness
- Co-morbid psychiatric, major medical, or neurological disorders
- History of withdrawal seizures, delirium tremens, or significant head injury
Other
- Presence of pacemaker or metal in any part of body (excluding mouth)
- Pregnant or lactating women
Who the study is looking for
- Diagnosed with treatment-resistant schizophrenia according to TRIIP Consensus criteria
- Age: 18-60 years
- Currently receiving clozapine treatment for at least 6 months
- Attending psychiatry outpatient department at AIIMS Bhubaneswar
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| AIIMS, Bhubaneswar Coordinator of this site? Confirm its status | Bhubaneswar | India | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.