NCT07445841Recruiting
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training: A Bayesian Adaptive Trial (PROTECT)
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these patients. Although physical exercise is usually recommended after stroke, there is very little information about the protective effect of exercise implemented in early stages of recovery as a potential protective measure against cognitive decline and dementia risk in these patients. This study will investigate the effect of a multimodal exercise intervention implemented early after the stroke event on cognition and on a selected group of markers that can predict cognitive decline and dementia risk.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 19 Feb 2026
- Start date
- 9 Mar 2026
- Primary completion date
- 30 Jan 2030
- Lead sponsor
- McGill University
- Diseases
- Stroke
- NCT number
- NCT07445841
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 9 Mar 2026 to the primary completion date, 30 Jan 2030
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medications that impact cognition
Other illness
- Diagnosed with dementia
- Participants will be excluded if they have been engaged in a structured exercise training program outside their regular in/out-patient hospital rehabilitation since suffering the stroke.
Other
- Absolute contraindications to exercise or MRI scanning
- Significant disability (modified Rankin score \>3)
- Co-morbidities that preclude exercise participation, pain worsened with exercise, and communication (e.g., severe aphasia) or behavioral issues limiting safe participation will also be reasons for exclusion.
Who the study is looking for
- medically stable
- have had a first-ever ischemic/hemorrhagic stroke confirmed by MRI/CT 0-6 months prior to participation.
- Able to independently walk at least 10 meters (assistive devices permitted) and capable of following instructions will be required.
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| McMaster University Coordinator of this site? Confirm its status | Hamilton | Canada | Active, not recruiting |
| Jewish Rehabilitation Hospital Coordinator of this site? Confirm its status | Laval | Canada | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.