NCT07446439RecruitingPhase 3
A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
The Thetis Study: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Tradipitant on Nausea and Vomiting After GLP-1R Agonist Administration in Healthy Overweight or Obese Volunteers
Source: ClinicalTrials.gov · Last updated 20 Apr 2026
Brief summary (registry, in English)
The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 280 (estimated)
- First submitted
- 10 Feb 2026
- Start date
- 27 Mar 2026
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- Vanda Pharmaceuticals
- Diseases
- Obesity
- NCT number
- NCT07446439
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 280
- From 27 Mar 2026 to the primary completion date, 1 Dec 2026
- 10 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Exposure to any investigational medication within the past 60 days
Other illness
- Another disorder that contributes to gastrointestinal symptoms
- History of intolerance and/or hypersensitivity to NK-1 receptor antagonists
- History of intolerance and/or hypersensitivity to GLP-1 receptor agonists
Who the study is looking for
- Body Mass Index ≥ 25 and \< 40 kg/m\^2
- No serious medical problems or chronic diseases, specifically no type I or type II diabetes
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| - Coordinator of this site? Confirm its status | Burke | United States | Not yet recruiting |
| - Coordinator of this site? Confirm its status | Hamilton | United States | Not yet recruiting |
| - Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| - Coordinator of this site? Confirm its status | New York | United States | Not yet recruiting |
| - Coordinator of this site? Confirm its status | Plano | United States | Not yet recruiting |
| - Coordinator of this site? Confirm its status | San Antonio | United States | Not yet recruiting |
| - Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| - Coordinator of this site? Confirm its status | San Jose | United States | Not yet recruiting |
| - Coordinator of this site? Confirm its status | Syosset | United States | Not yet recruiting |
| - Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.