NCT07446608Recruiting
MRI-Based Prediction of Dienogest Response in Endometriosis
Predicting the Efficacy of Dienogest in Patients With Endometriosis Using MRI
Source: ClinicalTrials.gov · Last updated 3 Mar 2026
Brief summary (registry, in English)
The goal of this prospective observational study is to learn whether magnetic resonance imaging (MRI) findings can help predict treatment response to dienogest in women with endometriosis. Endometriosis is a common gynecologic condition that can cause chronic pelvic pain and negatively affect quality of life. Although dienogest is widely used as a standard medical treatment, individual responses to treatment vary. The main questions this study aims to answer are: * Whether baseline MRI characteristics of endometriotic lesions are associated with improvement in pelvic pain after dienogest treatment. * Whether MRI findings can help identify patients who are more likely to benefit from dienogest therapy. Participants diagnosed with endometriosis who are prescribed dienogest as part of their routine clinical care will be enrolled. This study does not assign any investigational intervention. Participants will undergo standard clinical follow-up, including pelvic pain assessment using visual analog scale (VAS) scores, quality of life questionnaires, and routine MRI examinations. Clinical and imaging data will be collected prospectively and analyzed to explore imaging predictors of treatment response.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 48 (estimated)
- First submitted
- 19 Feb 2026
- Start date
- 14 Oct 2025
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Chungnam National University Sejong Hospital
- Diseases
- Endometriosis
- NCT number
- NCT07446608
What you commit to
- Study type: Observational
- Planned participants: 48
- From 14 Oct 2025 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with a history of treatment with dienogest
- Patients who are unable to undergo magnetic resonance imaging (MRI) (e.g., presence of metallic implants)
Other illness
- Patients with poor general medical condition, as judged by the investigator
Other
- Patients with contraindications to dienogest
- Patients who are currently pregnant or planning pregnancy within the next 6 months
Who the study is looking for
- Female participants who have received a full explanation of the study and have provided written informed consent
- Women aged 19 to 45 years who have been diagnosed with endometriosis by a board-certified obstetrician-gynecologist
- Patients who have not received any hormonal treatment within the previous 3 months
- Patients who have never been treated with dienogest
Age in the registry: 19 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sejong Chungnam National University Hospital Coordinator of this site? Confirm its status | Sejong | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.