NCT07446972Recruiting
Impact of Bariatric Surgery on Female Sexual Function and Sex Hormones
Impact of Bariatric Surgery on Female Sexual Function, Sex Hormones, and Psychological Well-Being: A Prospective Cohort Study With Partner Assessment
Source: ClinicalTrials.gov · Last updated 10 Jun 2026
Brief summary (registry, in English)
The goal of this observational study is to learn about how weight loss surgery (also called bariatric surgery) affects sexual function and sex hormone levels in women with severe obesity. It will also look at how the surgery affects mood, quality of life, body image, and the partner's sexual health. The main questions it aims to answer are: * Does sexual function improve after weight loss surgery? * Do sex hormone levels change after weight loss surgery? * Are these changes linked to improvements in mood and quality of life? * Does the partner also experience changes in sexual function? Researchers will compare each participant's results before surgery to their results 6 months after surgery. This helps show how things change over time. This study will include about 40 women who: * Are between 18 and 45 years old * Have severe obesity and are scheduled for weight loss surgery at Cairo University Hospital * Have a stable, sexually active partner relationship What participants will do: * Complete questionnaires about sexual function, mood, quality of life, and body image (twice: before surgery and 6 months after) * Provide a blood sample to measure sex hormone levels (before surgery and 6 months after) * Their partners will complete a short questionnaire about their own sexual function This research is important because sexual health is a key part of quality of life that is often overlooked in obesity care. Understanding how weight loss surgery affects sexual function, hormones, and mood can help doctors better counsel patients about what to expect after surgery. This is one of the first studies in Egypt to examine these questions and the first to include partner assessment. The study will start in January 2026. Results will be available by late 2026.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 26 Feb 2026
- Start date
- 5 Jun 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Cairo University
- Diseases
- Obesity
- NCT number
- NCT07446972
What you commit to
- Study type: Observational
- Planned participants: 40
- From 5 Jun 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antipsychotics/psychotropic drugs
- Hormone replacement therapy
- Partner with known erectile dysfunction or use of erectile dysfunction medications
- Previous bariatric surgery (revisional procedures)
Other illness
- History of medication use that can interfere with sexual function, including:
- Major uncontrolled medical conditions:
- History of pelvic floor surgery or gynecological malignancy
Other
- Women who are not sexually active
- Post-menopausal women (amenorrhea ≥12 months without other cause)
- Current pregnancy or lactation
- Antidepressants
- Beta-blockers
- Spironolactone
- Hormonal contraceptives (unless stable for ≥3 months and continued throughout study)
- Chronic heavy smoker (smoking index ≥400 pack-years)
- Inability or unwillingness to provide informed consent
Who the study is looking for
- Female gender
- Age 18-45 years (childbearing period)
- Body Mass Index (BMI) ≥40 kg/m² or ≥35 kg/m² with obesity-related comorbidities, meeting international criteria for bariatric surgery
- Scheduled for primary bariatric surgery (sleeve gastrectomy or Roux-en-Y gastric bypass)
- Presence of a stable, sexually active intimate partner relationship
- Sexually active
- Willingness to participate and provide informed consent
- Ability to complete Arabic-language questionnaires
Age in the registry: 18 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine Cairo University Coordinator of this site? Confirm its status | Cairo | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.