NCT07447440Recruiting
Role of Pro-Resolving Lipid Mediators in Obesity-Associated Diseases
Unraveling the Role of Pro-Resolving Lipid Mediators of Inflammation and Their Receptors in Obesity-Associated Diseases: New Therapeutic Approaches for Maresin 1 (RESOLBE)
Source: ClinicalTrials.gov · Last updated 11 Mar 2026
Brief summary (registry, in English)
The main objective of this project is to determine the possible association between the levels of certain bioactive lipids, which the body produces from dietary fatty acids, and tumor characteristics in breast cancer patients, as well as their relationship with overweight/obesity. Specific objectives are: * To analyse anthropometric and body composition changes. * To evaluate physical activity level. * To determine dietary profile. * To determine the adherence to Mediterranean dietary pattern. * To assess the quality of life. * To determine levels of specialized pro-resolving lipid mediators The target sample size is 60 subjects. Participants will be allocated in four groups: * Group 1: Postmenopausal healthy women with overweight/obesity (n=15) * Group 2: Postmenopausal healthy women with normoweight (n=15) * Group 3: Postmenopausal women with breast cancer and overweight/obesity (n=15) * Group 4: Postmenopausal women with breast cancer and normoweight (n=15)
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 25 Feb 2026
- Start date
- 15 Oct 2025
- Primary completion date
- 30 Nov 2027
- Lead sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
- Diseases
- Obesity, Childhood cancers
- NCT number
- NCT07447440
What you commit to
- Study type: Observational
- Planned participants: 60
- From 15 Oct 2025 to the primary completion date, 30 Nov 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current weight loss treatment (diet, supplementation, surgery, others...).
- Bariatric surgery.
- Surgical interventions resulting in permanent sequelae of the gastrointestinal tract.
Other illness
- Personal history of cancer.
- Diabetes treatment and hormone replacement therapy.
- Relevant functional or structural abnormalities of the gastrointestinal tract, such as malformations, angiodysplasias, active peptic ulcers, chronic inflammatory or malabsorption diseases, hiatal hernia, chronic reflux, etc.
- Liver disease, except for non-alcoholic fatty liver disease.
- Cognitive and/or psychiatric impairment.
- Poor compliance or difficulty following study procedures.
- BREAST CANCER PARTICIPANTS:
- Luminal subtype breast cancer stages over than II or other type of breast cancer.
Other
- No stable pharmacological treatment for at least 3 months.
- High alcohol intake, more than 14 units per week for women and 20 units per week for men.
- Require preoperative treatment.
Who the study is looking for
- Postmenopause (al least 1 year).
- Normoweight or overweight/obesity.
- No personal history of cancer.
- Stable weight over the last 3 months (±5%).
- Willing to sign the informed consent and comply with all study procedures.
- Postmenopause (at least 1 year).
- Normoweight or overweight/obesity.
- Luminal subtype breast cancer, stages I-II, who require tumor resection and do not require preoperative treatment.
- Willing to sign the informed consent and comply with all study procedures.
Criteria the registry did not label
- HEALTHY PARTICIPANTS:
Sex: Female · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Recruiting |
| Center for Nutrition Research Coordinator of this site? Confirm its status | Pamplona | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.