NCT07450534Not yet recruiting
The Practicality and Utility of Measured vs Estimated GFR in adCKD
The Practicality & Utility of Estimated vs Measured Renal Function in Advanced Kidney Disease, Whether Treated With Dialysis or Not: Can Better Techniques be Used to Predict the Onset of the Uraemic Syndrome and Guide Dialysis Requirements
Source: ClinicalTrials.gov · Last updated 4 Mar 2026
Brief summary (registry, in English)
The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis. The main questions the study is trying to answer is whether measuring kidney function by clearance of iohexol is comparable to the current standard of care methods. In addition to routine care, participants will: * undergo a brief clinical assessment * be given an injection of iohexol and asked to perform 4 finger prick blood tests over 24 hours, recording the time of each sample. Samples will be returned in person or posted back * be asked to complete a questionnaire on their experience
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 10 Feb 2026
- Start date
- Feb 2026
- Primary completion date
- Sept 2026
- Lead sponsor
- Manchester University NHS Foundation Trust
- Diseases
- Chronic kidney disease
- NCT number
- NCT07450534
What you commit to
- Study type: Observational
- Planned participants: 150
- From Feb 2026 to the primary completion date, Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pre-dialysis and planned renal transplant within 1 month
Other illness
- Known allergy to iodinated contrast media
Other
- Under 18 years
- Unable to perform fingerprick blood testing
- Unable to comply with urine collection
- Unable or unwilling to give informed consent in English
- Acute kidney injury expected to recover renal function
- Pregnant or breast feeding
- Significant fluid overload (significant peripheral oedema or ascites AND \>10kg above estimated dry weight)
Who the study is looking for
- Adults (18 year s or older)
- Able to give informed consent
- Progressive chronic kidney disease predicted to start renal replacement therapy in the next 6 months OR established on dialysis (either haemodialysis or peritoneal) with residual renal function (Urine output \>100ml/day)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Manchester Royal Infirmary Coordinator of this site? Confirm its status | Manchester | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.