NCT07450612Recruiting
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection
Source: ClinicalTrials.gov · Last updated 4 Mar 2026
Brief summary (registry, in English)
This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers. Additionally, a pre-planned analysis will evaluate the use of this liquid biopsy as a tool for molecular residual disease monitoring purposes.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1200 (estimated)
- First submitted
- 27 Feb 2026
- Start date
- 1 Jan 2024
- Primary completion date
- 15 Jan 2031
- Lead sponsor
- San Raffaele University
- Diseases
- Colorectal cancer
- NCT number
- NCT07450612
What you commit to
- Study type: Observational
- Planned participants: 1200
- From 1 Jan 2024 to the primary completion date, 15 Jan 2031
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Inflammatory bowel disease
Other
- Lack of informed consent
Who the study is looking for
- All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
- Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
- Received standard pathological and endoscopic diagnosis and assessment for cohort assignment
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dipartimento di Chirurgia Oncologica e Dipartimento di Oncologia Sperimentale Istituto Nazionale Tumori Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| Prof Giulia Martina Cavestro, MD PhD Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
| San Raffaele Scientific Institute, Gastroenterology and Gastrointestinal Endoscopy Unit Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Gastronterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Hospital Coordinator of this site? Confirm its status | Milan | Italy | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.