NCT07450846Recruiting
Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome
Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome: the IVOLIA Study
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection. It is treated by artificial ventilation with the application of positive pressure. Pulmonary injury, coupled with artificial ventilation, can lead to right heart failure which hinders the ejection of blood to the pulmonary circulation. Modern mechanical ventilation modalities have reduced the frequency ("incidence") of this right heart failure in acute respiratory distress syndrome. A large-scale study has shown this a few years ago. However, the evolution of right heart failure during artificial ventilation, and the consequences it has on the patient's cardiovascular status are poorly determined. This study is conducted to improve knowledge in this area. In adult patients hospitalized in intensive care presenting acute respiratory distress syndrome, the investigators will collect the data recorded on cardiac ultrasound, doses of cardiovascular drugs as well as variables reflecting hemodynamic status and cell oxygenation. Data will be collected during the course of ARDS and mechanical ventilation, as well as after weaning from artificial ventilation.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 16 Dec 2022
- Start date
- 22 Dec 2022
- Primary completion date
- Jan 2028
- Lead sponsor
- Bicetre Hospital
- Diseases
- Heart failure
- NCT number
- NCT07450846
What you commit to
- Study type: Observational
- Planned participants: 500
- From 22 Dec 2022 to the primary completion date, Jan 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Pregnancy Poor echogenicity preventing reliable measurement of the dimensions of the right and left ventricles.
Who the study is looking for
- Age ≥18 years old
- Hospitalization in intensive care undergoing mechanical ventilation
- Presence of ARDS according to the current consensus definition (Berlin definition)
- Performance of at least one echocardiography during the first 24 hours of treatment, between the 2nd and 3rd day, between the 5th and 7th day, and within 48 hours of extubation
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chu de Bicêtre, AP-HP Coordinator of this site? Confirm its status | Le Kremlin-Bicêtre | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.