NCT07452952Not yet recruiting
Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.
Source: ClinicalTrials.gov · Last updated 5 Mar 2026
Brief summary (registry, in English)
The main objective is to assess the effect of increased PEEP on echo-Doppler venous congestion in ARDS patients at two PEEP levels, by grading congestion in each venous flow (suprahepatic, renal, portal) as "absent," "moderate," or "severe," and also calculating the VExUS score.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 23 Jan 2026
- Start date
- 1 Mar 2026
- Primary completion date
- 1 Nov 2027
- Lead sponsor
- University Hospital, Angers
- Diseases
- Heart failure
- NCT number
- NCT07452952
What you commit to
- Study type: Observational
- Planned participants: 30
- From 1 Mar 2026 to the primary completion date, 1 Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Renal or hepatic transplant recipient
Other illness
- Congenital heart disease
- Portal vein thrombosis or Budd-Chiari syndrom
- Abdominal compartment syndrome documented by intra-abdominal pressure ≥20 mmHg
- Persons subject to compulsory psychiatric care
Age
- Minor patient (\<18 years old)
Other
- ECMO (Extracorporeal Membrane Oxygenation)
- Hemodynamic instability (mean arterial pressure \<60 mmHg)
- Respiratory instability (SpO₂ \<90% under FiO₂ \>90%)
- Severe organic tricuspid regurgitation
- Pneumothorax
- Liver cirrhosis Child-Pugh C
- Pregnant, breastfeeding, or peripartum women
- Persons deprived of liberty by judicial or administrative decision
- Persons under legal protective measures
Who the study is looking for
- Patients hospitalized in the Medical Intensive Care and Hyperbaric Medicine Unit of Angers University Hospital, receiving mechanical ventilation in assist-control mode (A/C ventilation), and presenting with ARDS as defined by the following criteria (1):
- Hypoxemia with a PaO₂ (mmHg)/FiO₂ (0.21 to 1.0) ratio \<300 mmHg with a positive end-expiratory pressure (PEEP) ≥5 cmH₂O;
- Pulmonary edema not fully explained by cardiac failure or fluid overload;
- Presence of bilateral pulmonary opacities on chest imaging not fully explained by pleural effusions, atelectasis, or pulmonary nodules.
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University hospital of Angers Coordinator of this site? Confirm its status | Angers | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.