NCT07453394Not yet recruitingPhase 1/2
QLS5132 Combination Therapy in Advanced Solid Tumors
A Phase Ib/II Clinical Study on the Safety, Tolerability, Pharmacokinetics, and Efficacy of Intravenous QLS5132 Combination Therapy in Participants With Advanced Solid Tumors
Source: ClinicalTrials.gov · Last updated 6 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics (PK), and effectiveness of the investigational drug QLS5132 (injectable) in combination with other therapies for participants with advanced solid tumors. This is a multicenter, open-label study consisting of two parts: dose escalation and tumor-specific expansion. The main questions it aims to answer are: * In the dose-escalation part: What is the safety, tolerability, PK profile, and preliminary efficacy of QLS5132 combination therapy, and what are the recommended dose(s) for expansion? * In the expansion part: What is the anti-tumor efficacy and further safety profile of QLS5132 combination therapy at the selected dose(s) in participants with specific tumor types? Participants will: * Be enrolled in sequential cohorts to receive QLS5132 in combination with other anticancer agents. * Undergo regular assessments for safety, drug concentration levels (PK), and tumor response.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 626 (estimated)
- First submitted
- 1 Mar 2026
- Start date
- Apr 2026
- Primary completion date
- Apr 2027
- Lead sponsor
- Qilu Pharmaceutical Co., Ltd.
- NCT number
- NCT07453394
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 626
- From Apr 2026 to the primary completion date, Apr 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous treatment with drugs targeting CLDN6 (including antibody-drug conjugates \[ADCs\]), or any drug containing topoisomerase I inhibitors (including ADCs);
- Received prior chemotherapeutic, investigational, or other therapies for the treatment of cancer within 2 weeks with small molecule and within 4 weeks with biologic before the first dose of QLS5132;
Other illness
- Serious, uncontrolled medical disorder, nonmalignant systemic disease, or active, uncontrolled infection;
- History of significant cardiac disease, or poorly controlled diabetes mellitus;
- History of recurrent autoimmune diseases;
- History of myelodysplastic syndrome (MDS) or Acute Myeloid Leukemia (AML);
- History of a second primary malignancy;
- Be allergic to any component of QLS5132 or its excipients.
Other
- Progressive or symptomatic brain metastases;
- If female, is pregnant or breastfeeding;
Who the study is looking for
- Advanced solid tumors;
- Measurable disease, per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 (v1.1);
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1;
- Adequate organ function;
- Recover from all reversible AEs from previous anti-tumor treatment (i.e., Grade ≤ 1, according to National Cancer Institute-Common Terminology Criteria for Adverse Events \[NCI-CTCAE\] v5.0), excluding alopecia (any grade) and Grade ≤ 2 neuropathy peripheral.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.