NCT07454681Not yet recruiting
MRI Assessment of Lung Airways in Cystic Fibrosis: Evaluate MRI's Ability to Detect Changes in Airway Structure .
Development of Magnetic Resonance Imaging Airway Segmentation to Assess and Monitor Cystic Fibrosis Lung Disease
Source: ClinicalTrials.gov · Last updated 6 Mar 2026
Brief summary (registry, in English)
This study is being done to determine whether MRI can produce high quality lung and airway images in healthy and CF patients and if MRI can be used to evaluate size and shape of the airways with computer assistance. This study will also repeat MRI experiments two years after the initial MRI scan to see if changes to airway size and shape are seen over time. In a subset of participants, we will investigate whether MRI results are repeatable and reproducible in the short-term one week after the initial MRI visit. This study will help understand if MRI based measurements of airway size and shape can be used as a monitoring tool that does not use x-ray radiation in patients with CF.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 76 (estimated)
- First submitted
- 20 Feb 2026
- Start date
- 15 Apr 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- The Hospital for Sick Children
- Diseases
- Cystic fibrosis
- NCT number
- NCT07454681
What you commit to
- Study type: Observational
- Planned participants: 76
- From 15 Apr 2026 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Usage of oral antibiotics within 3 weeks prior to study visit
- Worsening cough and/or sputum production within the past 3 days prior to study visit
- The use of new oral and/or inhaled antibiotics within 3 weeks prior to study visit
- Received intravenous antibiotics within 2 weeks prior to study visit
- Status of post lung or another organ transplant
Other illness
- Known pulmonary disease
- Group 2 Inclusion Criteria
Age
- Participants must be greater than or equal to 6 years of age and not greater than 18 years of age.
Other
- Medical instability that would preclude the ability to undergo the required investigations
- FEV1 % predicted \< 40%
- Severe claustrophobia
- Does not meet MRI screening criteria
- Diagnosis of CF as evidenced by one or more clinical feature consistent with the CF phenotype or positive CF newborn screen
- Informed consent by patient or parent/guardian consent and participant assent when appropriate.
- Able to perform reproducible spirometry
- Medical instability that would preclude the ability to undergo the required investigations
- FEV1 % predicted \< 40%
- Severe claustrophobia
- Does not meet MRI screening criteria
- The use of supplementary oxygen
Who the study is looking for
- Participants must be greater than or equal to 6 years of age and not greater than 18 years of age.
- Informed consent by patient or parent/guardian consent and participant assent when appropriate.
- Able to perform reproducible spirometry
Criteria the registry did not label
- Group 1
Age in the registry: 6 years to 18 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital for Sick Children Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.