NCT07458217Recruiting
Combined CM and STN Stimulation for Motor Epilepsy
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
This self-crossover, randomized controlled, pilot study aims to collect clinical data of bilateral stimulation of subthalamic nucleus (STN) combined with centromedian (CM) thalamus deep brain stimulation (DBS) for drug resistant epilepsy with motor symptom in adults.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 4 Mar 2026
- Start date
- 13 Oct 2026
- Primary completion date
- 31 May 2028
- Lead sponsor
- Boston Scientific Corporation
- Diseases
- Epilepsy
- NCT number
- NCT07458217
What you commit to
- Study type: Interventional
- Planned participants: 10
- From 13 Oct 2026 to the primary completion date, 31 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 2\) Previous diagnosis of psychogenic/non-epileptic seizures.
- 3\) Brain lesion resection or ablation surgery performed less than 6 months.
Other illness
- 1\) Non Motor Epilepsy.
Other
- 4\) Implanted Vagus nerve stimulation (VNS) or responsive neurostimulation (RNS) devices recommended neither stimulation off the device at least 6 months nor remove the device.
- 5\) Pregnant, breastfeeding, or having the intention to become pregnant during the study period (for females of childbearing potential).
Who the study is looking for
- 1\) 18-65 Years.
- 2\) Drug Resistant Epilepsy.
- 3\) Motor Epilepsy - defined as:
- Epilepsy diagnosis meeting ILAE criteria
- Motor Epilepsy defined as including one or more of:
- Tonic, Clonic, or Tonic-Clonic activity; ii. Myoclonic Jerks; iii.Epileptic Spasms; iv.Focal Motor Seizures (identified primary lesion will be in motor functional area, such as primary motor cortex (BA4), pre-motor cortex (BA6), Central Posterior Gyrus (BA1-3), or other motor region); v.Motor activity not secondary to non-motor seizure. c.Clinical or Electrographic corroboration of at least one of: i.Video-EEG confirmation of motor seizure semiology; ii.Interictal or ictal EEG findings consistent with epileptic motor network involvement; iii.Consistent clinical description by trained cliniciants.
- 4\) \>3 Focal or Generalized seizures / month with an inter-seizure interval no great than 30 days.
- 5\) Subject or caregiver is able to provide epileptic seizure record within 90 days prior to the surgery.
- 6\) Voluntarily participate in the trial, sign the informed consent form, and be willing to comply with study requirements, including follow-ups.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xuanwu Hospital Capital Medical Univers Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.