NCT07460999Recruiting
Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC)
Effects and Mechanisms of Online Delivered Singing Training vs Usual Care in Patients With Persistent Symptoms 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC) - a Multi-centre RCT
Source: ClinicalTrials.gov · Last updated 2 Apr 2026
Brief summary (registry, in English)
People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning. Current Danish rehabilitation offers are heterogeneous and inconsistent and not tailored to the specific needs of this population. Additionally, some patients continue to suffer from persistent physical symptoms months or even years after surgery, yet no targeted support is currently available for them. Singing - delivered as a structured form of training - has shown benefits in improving both physical and psychological outcomes in individuals with chronic obstructive pulmonary disease (COPD). Although singing has not yet been studied in NSCLC patients, the two conditions share overlapping symptoms and characteristics. Therefore, the present study aims to explore whether a singing-based intervention can help reduce symptom burden and improve physical function and QoL in NSCLC patients 6 to 18 months post-surgery. To test this, a multi-centre randomised controlled trial (RCT) will be conducted, comparing a singing intervention to usual care. Given that travel and distance often pose significant barriers to participation, the intervention will be delivered online.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 20 Jan 2026
- Start date
- 1 Mar 2026
- Primary completion date
- 1 Apr 2027
- Lead sponsor
- Zealand University Hospital
- Diseases
- Lung cancer
- NCT number
- NCT07460999
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Mar 2026 to the primary completion date, 1 Apr 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Indication for adjuvant chemotherapy or other antineoplastic therapy,
- Signs of lung cancer recurrence at regular follow-up CT scan.
- No previous singing experience or musical competence is required. Participants will be informed that they are allowed to participate in additional offer of structured or unstructured offer physical exercise training and/or singing along with the project.
Other illness
- Unstable coronary diseases,
- Severe cognitive disabilities (e.g., dementia),
Who the study is looking for
- Patients who display persistent symptoms 6-18 months (+/- one month) after surgical resection of localised lung cancer with video-assisted thoracoscopy (VATS) will be invited to participate in the study.
- Persistent symptoms, i.e., an EORTC-QLQ-C30 symptom domain score (in any item) of ≥2 (="clinically relevant symptom or problem that should have healthcare professional attention"),
- Surgery for stage I lung cancer 6-18 months (+/- one month) earlier,
- Motivated for participating in the project (and acceptance of randomisation procedure),
- Access to a computer or a tablet with internet access,
- Ability to speak and understand Danish,
- Acceptance of the scheduled times of the singing intervention twice a week.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| August Krogh Section for Molecular and Human Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Health and Medical Sciences, University of Copenhagen Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| Department of Respiratory Medicine, Bispebjerg Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
| Department of Medicine Roskilde and Næstved, Zealand University Hospital Coordinator of this site? Confirm its status | Næstved | Denmark | Recruiting |
| Department of Respiratory Medicine, Odense University Hospital Coordinator of this site? Confirm its status | Odense | Denmark | Recruiting |
| Department of Respiratory Medicine, Lillebaelt Hospital Coordinator of this site? Confirm its status | Vejle | Denmark | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.