NCT07461350Enrolling by invitation
Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV
Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV (SPISE)
Source: ClinicalTrials.gov · Last updated 11 Aug 2026
Brief summary (registry, in English)
This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 20 Feb 2026
- Start date
- 5 Aug 2026
- Primary completion date
- 31 Mar 2030
- Lead sponsor
- University of California, San Francisco
- Diseases
- HIV
- NCT number
- NCT07461350
What you commit to
- Study type: Observational
- Planned participants: 400
- From 5 Aug 2026 to the primary completion date, 31 Mar 2030
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- metal implants,
Lab values
- visit day eGFR\<45 ml/min/1.73 m2;
Other
- Standard contraindications to MRI
- claustrophobia,
- large body size (weight \>350 lbs or abdominal sagittal diameter \>70 cm),
- pregnancy)
- Gadolinium risk
- severe or uncontrolled asthma,
- poor venous access
- pregnancy or lactation
Who the study is looking for
- \- Participants with and without HIV enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) Atlanta, Baltimore, Bronx, and San Francisco study sites
Age in the registry: 30 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emory University School of Medicine Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Johns Hopkins University Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| Albert Einstein College of Medicine Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.