NCT07461610Recruiting
Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass
Routine Stool Parameters Six Months After Sleeve Gastrectomy vs. Gastric Bypass: Correlation With Weight Loss and Metabolic Outcomes
Source: ClinicalTrials.gov · Last updated 18 May 2026
Brief summary (registry, in English)
The goal of this observational study is to learn whether routine stool tests can detect changes in gut function 6 months after two common types of weight loss surgery: sleeve gastrectomy and gastric bypass (including mini gastric bypass and Roux-en-Y gastric bypass). The main questions it aims to answer are: Do stool tests show more signs of undigested food or carbohydrate malabsorption after gastric bypass compared to sleeve gastrectomy? Do signs of gut inflammation in stool (like fecal calprotectin) decrease after surgery, and does this relate to improvements in blood sugar and weight loss? Can simple stool test results at 6 months predict how much weight a person loses or how well their diabetes improves? Researchers will compare stool test results between the two surgery groups (sleeve gastrectomy vs. gastric bypass) to see if the type of surgery leads to different changes in gut health. Participants will: Provide a stool sample before surgery and again 6 months after surgery Provide a blood sample at the same time points to measure weight, blood sugar, and cholesterol Undergo their planned weight loss surgery as part of their regular medical care
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 4 Mar 2026
- Start date
- 5 Apr 2026
- Primary completion date
- Nov 2026
- Lead sponsor
- Cairo University
- Diseases
- Obesity
- NCT number
- NCT07461610
What you commit to
- Study type: Observational
- Planned participants: 50
- From 5 Apr 2026 to the primary completion date, Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous bariatric surgery or major gastrointestinal surgery (gastric, intestinal, or colorectal resection)
- Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to stool sample collection (to avoid confounding effects on gut flora)
Other illness
- Chronic liver disease (cirrhosis, chronic hepatitis) or liver failure
- Chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, or chronic pancreatitis
- Active malignancy or history of chemotherapy/radiotherapy in the past 5 years
- Acute gastrointestinal infection at the time of sample collection
Lab values
- Chronic kidney disease (eGFR \< 60 mL/min/1.73m²) or previous renal transplant
Age
- Age \< 18 years or \> 60 years
Other
- Pregnancy or breastfeeding
- Chronic alcohol abuse or substance abuse
Who the study is looking for
- Male and female patients aged 18 to 60 years
- Body Mass Index (BMI) ≥ 40 kg/m², OR BMI ≥ 35 kg/m² with at least one obesity-related comorbidity (type 2 diabetes, hypertension, dyslipidemia, osteoarthritis, obstructive sleep apnea)
- Patients scheduled for primary laparoscopic bariatric surgery (either SG or Gastric Bypass \[MGB or RYGB\]) at Kasr Al-Ainy University Hospitals
- Provision of written informed consent
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine Cairo University Coordinator of this site? Confirm its status | Cairo | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.