NCT07461662Not yet recruiting
Evaluation of Endobronchial Ultrasound Needle Cleaning Techniques and Their Impact on Specimen Contamination
Source: ClinicalTrials.gov · Last updated 10 Mar 2026
Brief summary (registry, in English)
Endobronchial ultrasound (EBUS) bronchoscopy is commonly used to sample lymph nodes in patients with suspected or known lung cancer to determine the stage of the disease. Accurate staging is essential as it directly impacts treatment decisions and prognosis. During EBUS procedures, needles are often reused across multiple lymph node stations and are typically flushed with saline between samples. This raises the concern that residual tumor cells may contaminate the samples and could potentially incorrectly upstage disease. This prospective study will evaluate the current technique used during EBUS procedures to determine if more intensive cleaning leads to reduced cellular contamination without affecting diagnostics. Patients undergoing an EBUS procedure for diagnosis with a large mass and a high probability of malignancy will be selected for the study. Rapid On-Site Examination (ROSE) will be used at the bedside to determine the presence of abnormal cells. Following the final pass, before moving to the next station, the needle will be flushed with saline as normal and then flushed again into another container to evaluate the presence of residual cells. The outcome may help EBUS needle handling practices and improve lung cancer staging accuracy. No additional invasive procedures are performed as part of this study; all analyses utilize material obtained during routine EBUS needle flushing, with no added needle sticks or alteration of clinical care.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 204 (estimated)
- First submitted
- 16 Feb 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 31 May 2027
- Lead sponsor
- University of Mississippi Medical Center
- Diseases
- Lung cancer
- NCT number
- NCT07461662
What you commit to
- Study type: Interventional
- Planned participants: 204
- From 1 Apr 2026 to the primary completion date, 31 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent (1 month or less) radiation or procedural manipulation of lymph node stations that may significantly change lymph node architecture
Age
- Age less than 18
Who the study is looking for
- Adults aged 18 years or older
- Patients undergoing standard-of-care EBUS bronchoscopy for evaluation of suspected lung malignancy
- Patients undergoing sampling of 2 or more lymph node stations during EBUS bronchoscopy
- Ability to provide informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Mississippi Medical Center Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.