NCT07462000Recruiting
Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract
Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients
Source: ClinicalTrials.gov · Last updated 10 Mar 2026
Brief summary (registry, in English)
This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 9 Feb 2026
- Start date
- 21 Jan 2026
- Primary completion date
- 21 Jan 2027
- Lead sponsor
- Military Institute od Medicine National Research Institute
- Diseases
- Glaucoma
- NCT number
- NCT07462000
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 21 Jan 2026 to the primary completion date, 21 Jan 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Active or previous uveitis.
Other illness
- Advanced visual impairment in the study eye (visual aquity worse than counting fingers).
- History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery.
- Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm).
Age
- Age \< 18 years.
Other
- Pregnancy or breastfeeding.
- Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma).
- Inability to comply with study procedures or follow-up visits.
Who the study is looking for
- Age ≥ 18 years.
- Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation).
- Ability to provide written informed consent.
- For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure.
- For control arm: cataract without glaucoma and without other significant ocular pathology.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Military Institute of Medicine - National Research Institute Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
| University of Warsaw Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.