NCT07463898Recruiting
A Study to Find and Confirm Blood-based Markers (Called Proteins) That May Show Early Heart Changes in Women With Preeclampsia, Even Before Symptoms Appear, and the Use of Heart Ultrasound (Echocardiography) to Look at Patterns of How the Heart Changes During Pregnancy in Women With Preeclampsia
PRoteomics and EchoCardiography for Identifying Subclinical Cardiac Dysfunction in Preeclampsia (PRECISE)
Source: ClinicalTrials.gov · Last updated 27 Aug 2026
Brief summary (registry, in English)
The goal of this study is to find and confirm blood-based markers (called proteins) that may show early heart changes in women with preeclampsia, even before symptoms appear. It will also use heart ultrasound (echocardiography) to look at patterns of how the heart changes during pregnancy in women with preeclampsia. The main questions it aims to answer are: * Do these blood markers relate to heart changes on ultrasound? * How may they help predict future health problems for the mother? Participants will: * Complete a 20-minute survey that will include taking your baseline demographic information, clinical information/medical history, asking about pre-existing health conditions, including measuring your height, weight, and blood pressure. * Have transthoracic echocardiography (TTE) performed at 12 - 16 weeks gestation and again at 28 - 32 weeks gestation. * Provide a blood sample for these protein measurements. These samples will be collected at intake (12 - 16 weeks gestation) and again at 28 - 32 weeks gestation.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 172 (estimated)
- First submitted
- 5 Mar 2026
- Start date
- 24 Apr 2026
- Primary completion date
- May 2027
- Lead sponsor
- Washington University School of Medicine
- NCT number
- NCT07463898
What you commit to
- Study type: Observational
- Planned participants: 172
- From 24 Apr 2026 to the primary completion date, May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- • Known cardiac disease (e.g., cardiomyopathy, coronary artery disease \[CAD\])
- Sickle cell disease
- Pulmonary arterial hypertension
- Pulmonary embolism
- Inability to provide informed consent
- Acute Illness
- Malignancy
Who the study is looking for
- • Pregnant women who are up to 20 weeks pregnant
- Able to consent to participate in the study
- Are enrolled in the ENHANCE-CVH study
- Willing to undergo echocardiography and blood draws
Age in the registry: 13 years to 50 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Abuja Teaching Hospital Coordinator of this site? Confirm its status | Abuja | Nigeria | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.